Macrophage-derived extracellular vesicles: diverse mediators of pathology and therapeutics in multiple diseases

Y Wang, M Zhao, S Liu, J Guo, Y Lu, J Cheng… - Cell death & …, 2020 - nature.com
Macrophages (Mφ) are primary innate immune cells that exhibit diverse functions in
response to different pathogens or stimuli, and they are extensively involved in the …

Extracellular vesicles in fungi: past, present, and future perspectives

J Rizzo, ML Rodrigues, G Janbon - Frontiers in Cellular and Infection …, 2020 - frontiersin.org
Extracellular vesicles (EVs) have garnered much interest in the cell biology and biomedical
research fields. Many studies have reported the existence of EVs in all types of living cells …

[HTML][HTML] Exosomes from M1-polarized macrophages enhance paclitaxel antitumor activity by activating macrophages-mediated inflammation

P Wang, H Wang, Q Huang, C Peng, L Yao, H Chen… - Theranostics, 2019 - ncbi.nlm.nih.gov
Objective: Exosomes (Exos) are membrane-encased vesicles derived by nearly all cell types
for intercellular communication and regulation. They also received attention for their use as …

Inflammation leads to distinct populations of extracellular vesicles from microglia

Y Yang, A Boza-Serrano, CJR Dunning… - Journal of …, 2018 - Springer
Background Activated microglia play an essential role in inflammatory responses elicited in
the central nervous system (CNS). Microglia-derived extracellular vesicles (EVs) are …

New Insights in Candida albicans Innate Immunity at the Mucosa: Toxins, Epithelium, Metabolism, and Beyond

A Pellon, SD Sadeghi Nasab… - Frontiers in cellular and …, 2020 - frontiersin.org
The mucosal surfaces of the human body are challenged by millions of microbes on a daily
basis. Co-evolution with these microbes has led to the development of plastic mechanisms …

The IL4I1 enzyme: a new player in the immunosuppressive tumor microenvironment

The high metabolic needs of T lymphocytes in response to activation make them particularly
vulnerable to modifications of their biochemical milieu. Immunosuppressive enzymes …

Candida albicans induces cross-kingdom miRNA trafficking in human monocytes to promote fungal growth

LD Halder, S Babych, DI Palme… - MBio, 2022 - Am Soc Microbiol
In response to infections, human immune cells release extracellular vesicles (EVs) that carry
a situationally adapted cocktail of proteins and nucleic acids, including microRNAs …

Candida albicans hyphal extracellular vesicles are different from yeast ones, carrying an active proteasome complex and showing a different role in host immune …

R Martínez-López, ML Hernáez, E Redondo… - Microbiology …, 2022 - Am Soc Microbiol
Candida albicans is the principal causative agent of lethal fungal infections, predominantly
in immunocompromised hosts. Extracellular vesicles (EVs) have been described as crucial …

Identification of state-specific proteomic and transcriptomic signatures of microglia-derived extracellular vesicles

JV Santiago, A Natu, CC Ramelow, S Rayaprolu… - Molecular & Cellular …, 2023 - ASBMB
Microglia are resident immune cells of the brain that play important roles in mediating
inflammatory responses in several neurological diseases via direct and indirect …

Immune modulation by complement receptor 3-dependent human monocyte TGF-β1-transporting vesicles

LD Halder, EAH Jo, MZ Hasan… - Nature …, 2020 - nature.com
Extracellular vesicles have an important function in cellular communication. Here, we show
that human and mouse monocytes release TGF-β1-transporting vesicles in response to the …