About twenty years ago, the functional lipid raft model of the plasma membrane was
published. It took into account decades of research showing that cellular membranes are not …

Sphingomyelin synthase (SMS), which comprises of two isozymes, SMS1 and SMS2, is the
only enzyme that generates sphingomyelin (SM) by transferring phosphocholine of …

The serine/threonine kinase Akt is a master regulator of many diverse cellular functions,
including survival, growth, metabolism, migration, and differentiation. Receptor tyrosine …

Spatial compartmentalization of signaling pathway components generally defines the
specificity and enhances the efficiency of signal transduction. The phosphatidylinositol 3 …

Epithelial cells form a barrier against the environment, but are also required for the regulated
exchange of molecules between an organism and its surroundings. Epithelial cells are …

Diabetes mellitus is a metabolic disease with multiple complications that causes serious
diseases over the years. The condition leads to severe economic consequences and is …

We have previously demonstrated that hexanoyl-d-erythro-sphingosine (C 6-ceramide), an
anti-mitogenic cell-permeable lipid metabolite, limited vascular smooth muscle growth by …

C eramide and sphingosine-1-phosphate are related sphingolipid metabolites that can be
generated through a de novo biosynthetic route or derived from the recycling of membrane …

Defeating pancreatic cancer resistance to the chemotherapeutic drug gemcitabine remains
a challenge to treat this deadly cancer. Targeting the sphingolipid metabolism for improving …

Elevated ceramide concentrations in adipocytes and skeletal muscle impair PKB (protein
kinase B; also known as Akt)-directed insulin signalling to key hormonal end points. An …