[HTML][HTML] Ginsenosides in Panax genus and their biosynthesis

M Hou, R Wang, S Zhao, Z Wang - Acta Pharmaceutica Sinica B, 2021 - Elsevier
Ginsenosides are a series of glycosylated triterpenoids which belong to protopanaxadiol
(PPD)-, protopanaxatriol (PPT)-, ocotillol (OCT)-and oleanane (OA)-type saponins known as …

Recent advances in triterpenoid pathway elucidation and engineering

S Dinday, S Ghosh - Biotechnology Advances, 2023 - Elsevier
Triterpenoids are among the most assorted class of specialized metabolites found in all the
taxa of living organisms. Triterpenoids are the leading active ingredients sourced from plant …

Characterization of the horse chestnut genome reveals the evolution of aescin and aesculin biosynthesis

W Sun, Q Yin, H Wan, R Gao, C Xiong, C Xie… - Nature …, 2023 - nature.com
Horse chestnut (Aesculus chinensis) is an important medicinal tree that contains various
bioactive compounds, such as aescin, barrigenol-type triterpenoid saponins (BAT), and …

Repeated evolution of cytochrome P450-mediated spiroketal steroid biosynthesis in plants

B Christ, C Xu, M Xu, FS Li, N Wada, AJ Mitchell… - Nature …, 2019 - nature.com
Diosgenin is a spiroketal steroidal natural product extracted from plants and used as the
single most important precursor for the world steroid hormone industry. The sporadic …

A cellulose synthase-derived enzyme catalyses 3-O-glucuronosylation in saponin biosynthesis

SY Chung, H Seki, Y Fujisawa, Y Shimoda… - Nature …, 2020 - nature.com
Triterpenoid saponins are specialised metabolites distributed widely in the plant kingdom
that consist of one or more sugar moieties attached to triterpenoid aglycones. Despite the …

Triterpenoid-biosynthetic UDP-glycosyltransferases from plants

S Rahimi, J Kim, I Mijakovic, KH Jung, G Choi… - Biotechnology …, 2019 - Elsevier
Triterpenoid saponins are naturally occurring structurally diverse glycosides of triterpenes
that are widely distributed among plant species. Great interest has been expressed by …

Plant triterpenoid saponins: biosynthesis, in vitro production, and pharmacological relevance

T Biswas, UN Dwivedi - Protoplasma, 2019 - Springer
The saponins are a diverse class of natural products, with a broad scale distribution across
different plant species. Chemically characterized as triterpenoid glycosides, they posses a …

[HTML][HTML] A translational synthetic biology platform for rapid access to gram-scale quantities of novel drug-like molecules

J Reed, MJ Stephenson, K Miettinen, B Brouwer… - Metabolic …, 2017 - Elsevier
Plants are an excellent source of drug leads. However availability is limited by access to
source species, low abundance and recalcitrance to chemical synthesis. Although plant …

[HTML][HTML] Synergistic mechanisms of constituents in herbal extracts during intestinal absorption: Focus on natural occurring nanoparticles

Q Zhao, X Luan, M Zheng, XH Tian, J Zhao, WD Zhang… - Pharmaceutics, 2020 - mdpi.com
The systematic separation strategy has long and widely been applied in the research and
development of herbal medicines. However, the pharmacological effects of many bioactive …

Draft genome assembly and annotation of Glycyrrhiza uralensis, a medicinal legume

K Mochida, T Sakurai, H Seki, T Yoshida… - The Plant …, 2017 - Wiley Online Library
Chinese liquorice/licorice (Glycyrrhiza uralensis) is a leguminous plant species whose roots
and rhizomes have been widely used as a herbal medicine and natural sweetener. Whole …