During development, cardiogenesis is orchestrated by a family of heart progenitors that build
distinct regions of the heart. Each region contains diverse cell types that assemble to form …

Myocardial infarction (MI) remains one of the leading cause of mortality over the world.
However, current treatments are more palliative than curative, which only stall the …

Human genetic variants predicted to cause loss-of-function of protein-coding genes (pLoF
variants) provide natural in vivo models of human gene inactivation and can be valuable …

Aims Cardiovascular disease, one of the most common causes of death in western
populations, is characterized by changes in RNA splicing and expression. Circular RNAs …

The capacity of pluripotent stem cells both for self-renewal and to differentiate into any cell
type have made them a powerful tool for studying human disease. Protocols for efficient …

Genetic cardiomyopathies are characterized by changes in the function and structure of the
myocardium. The development of a novel in vitro model could help to better emulate healthy …

Detailed characterization of cell type transitions is essential for cell biology in general and
particularly for the development of stem cell-based therapies in regenerative medicine. To …

There is a great need for physiologically relevant 3D human cardiac scaffolds for both short-
term, the development of drug testing platforms to screen new drugs across different genetic …

Stem cell therapy has obtained extensive consensus to be an effective method for post
myocardial infarction (MI) intervention. Induced pluripotent stem (iPS) cells, which are able …

Rationale: NAA15 (N-alpha-acetyltransferase 15) is a component of the NatA (N-terminal
acetyltransferase complex). The mechanism by which NAA15 haploinsufficiency causes …