The construction of biomimetic vasculatures within the artificial tissue models or organs is
highly required for conveying nutrients, oxygen, and waste products, for improving the …

Oxidative stress resulting from the accumulation of high levels of reactive oxygen species is
a salient feature of, and a well-recognised pathological factor for, diverse pathologies. One …

Different blood flow patterns in the arteries can alter the adaptive phenotype of vascular
endothelial cells (ECs), thereby affecting the functions of ECs and are directly associated …

An increase in intracellular Ca2+ concentration ([Ca2+] i) controls virtually all endothelial
cell functions and is, therefore, crucial to maintain cardiovascular homeostasis. An aberrant …

Transient receptor potential (TRP) proteins are a large group of ion channels that control
many physiological functions in our body. These channels are considered potential …

Diabetic nephropathy (DN) is an important public health concern of increasing proportions
and the leading cause of end-stage renal disease (ESRD) in diabetic patients. It is one of the …

Store-operated Ca2+ entry (SOCE) is activated in response to the inositol-1, 4, 5-
trisphosphate (InsP3)-dependent depletion of the endoplasmic reticulum (ER) Ca2+ store …

Oxidative stress and immune response play an important role in the development of several
cancers, including melanoma. Ion channels are aberrantly expressed in tumour cells and …

Our respiratory system is exposed to toxicants and pathogens from both sides: the airways
and the vasculature. While tracheal, bronchial and alveolar epithelial cells form a natural …

Transient receptor potential vanilloid 4 (TRPV4) channels are widely expressed in systemic
tissues and can be activated by many stimuli. TRPV4, a Ca2+-permeable cation channel …