Biologic therapies for severe asthma
GG Brusselle, GH Koppelman - New England Journal of …, 2022 - Mass Medical Soc
Biologic Therapies for Severe Asthma Patients with severe asthma are at increased risk for a
decreased quality of life, fixed airway obstruction, hospitalization, and death. Biologics may …
decreased quality of life, fixed airway obstruction, hospitalization, and death. Biologics may …
Does the epithelial barrier hypothesis explain the increase in allergy, autoimmunity and other chronic conditions?
CA Akdis - Nature Reviews Immunology, 2021 - nature.com
There has been a steep increase in allergic and autoimmune diseases, reaching epidemic
proportions and now affecting more than one billion people worldwide. These diseases are …
proportions and now affecting more than one billion people worldwide. These diseases are …
2021 American College of Rheumatology/Vasculitis Foundation guideline for the management of antineutrophil cytoplasmic antibody–associated vasculitis
SA Chung, CA Langford, M Maz, A Abril… - Arthritis & …, 2021 - Wiley Online Library
Objective To provide evidence‐based recommendations and expert guidance for the
management of antineutrophil cytoplasmic antibody–associated vasculitis (AAV), including …
management of antineutrophil cytoplasmic antibody–associated vasculitis (AAV), including …
[HTML][HTML] Interplay between inflammation and thrombosis in cardiovascular pathology
K Stark, S Massberg - Nature Reviews Cardiology, 2021 - nature.com
Thrombosis is the most feared complication of cardiovascular diseases and a main cause of
death worldwide, making it a major health-care challenge. Platelets and the coagulation …
death worldwide, making it a major health-care challenge. Platelets and the coagulation …
[HTML][HTML] Efficacy and safety of itepekimab in patients with moderate-to-severe asthma
ME Wechsler, MK Ruddy, ID Pavord… - New England journal …, 2021 - Mass Medical Soc
Abstract Background Monoclonal antibodies targeting IgE, interleukin-4 and-13, and
interleukin-5 are effective in treating severe type 2 asthma, but new targets are needed …
interleukin-5 are effective in treating severe type 2 asthma, but new targets are needed …
Mepolizumab for chronic rhinosinusitis with nasal polyps (SYNAPSE): a randomised, double-blind, placebo-controlled, phase 3 trial
JK Han, C Bachert, W Fokkens… - The Lancet …, 2021 - thelancet.com
Background Chronic rhinosinusitis with nasal polyps affects approximately 2–4% of the
general population, and long-term use of systemic corticosteroids is associated with adverse …
general population, and long-term use of systemic corticosteroids is associated with adverse …
[HTML][HTML] Current understanding of asthma pathogenesis and biomarkers
N Habib, MA Pasha, DD Tang - Cells, 2022 - mdpi.com
Asthma is a heterogeneous lung disease with variable phenotypes (clinical presentations)
and distinctive endotypes (mechanisms). Over the last decade, considerable efforts have …
and distinctive endotypes (mechanisms). Over the last decade, considerable efforts have …
[HTML][HTML] Eosinophils in health and disease: a state-of-the-art review
Eosinophils play a homeostatic role in the body's immune responses. These cells are
involved in combating some parasitic, bacterial, and viral infections and certain cancers and …
involved in combating some parasitic, bacterial, and viral infections and certain cancers and …
Biologics and airway remodeling in severe asthma
Asthma is a chronic inflammatory airway disease resulting in airflow obstruction, which in
part can become irreversible to conventional therapies, defining the concept of airway …
part can become irreversible to conventional therapies, defining the concept of airway …
[HTML][HTML] The polygenic and monogenic basis of blood traits and diseases
Blood cells play essential roles in human health, underpinning physiological processes
such as immunity, oxygen transport, and clotting, which when perturbed cause a significant …
such as immunity, oxygen transport, and clotting, which when perturbed cause a significant …