A systematic review of association studies investigating genes coding for serotonin receptors and the serotonin transporter: I. Affective disorders
M Anguelova, C Benkelfat, G Turecki - Molecular psychiatry, 2003 - nature.com
Abstract The different 5-HT (serotonin) receptors including the serotonin transporter (5-HTT)
are candidate genes for affective disorders such as major depressive disorder (MDD) and …
are candidate genes for affective disorders such as major depressive disorder (MDD) and …
Pharmacogenetics of antidepressant response
Personalized medicine—the adaptation of therapies based on an individual's genetic and
molecular profile—is one of the most promising aspects of modern medicine. The …
molecular profile—is one of the most promising aspects of modern medicine. The …
Early-life blockade of the 5-HT transporter alters emotional behavior in adult mice
MS Ansorge, M Zhou, A Lira, R Hen, JA Gingrich - Science, 2004 - science.org
Reduced serotonin transporter (5-HTT) expression is associated with abnormal affective and
anxiety-like symptoms in humans and rodents, but the mechanism of this effect is unknown …
anxiety-like symptoms in humans and rodents, but the mechanism of this effect is unknown …
Poor replication of candidate genes for major depressive disorder using genome-wide association data
FJ Bosker, CA Hartman, IM Nolte, BP Prins… - Molecular …, 2011 - nature.com
Abstract Data from the Genetic Association Information Network (GAIN) genome-wide
association study (GWAS) in major depressive disorder (MDD) were used to explore …
association study (GWAS) in major depressive disorder (MDD) were used to explore …
Altered depression-related behaviors and functional changes in the dorsal raphe nucleus of serotonin transporter-deficient mice
A Lira, M Zhou, N Castanon, MS Ansorge, JA Gordon… - Biological …, 2003 - Elsevier
BACKGROUND: As a key regulator of serotonergic activity and target of many
antidepressant treatments, the serotonin transporter (SERT) represents a potential mediator …
antidepressant treatments, the serotonin transporter (SERT) represents a potential mediator …
Neurodevelopmental origins of depressive disorders
MS Ansorge, R Hen, JA Gingrich - Current opinion in pharmacology, 2007 - Elsevier
Depression is a common and devastating neuropsychiatric disorder, and a better
understanding of its pathophysiology is needed to improve diagnosis, treatment and …
understanding of its pathophysiology is needed to improve diagnosis, treatment and …
Association between serotonin transporter gene promoter polymorphism (5HTTLPR) and behavioral responses to tryptophan depletion in healthy women with and …
A Neumeister, A Konstantinidis, J Stastny… - Archives of general …, 2002 - jamanetwork.com
Background Evidence suggests that serotonin transporter gene promoter polymorphism
(5HTTLPR)–dependent low transcriptional activity of the human serotonin transporter gene …
(5HTTLPR)–dependent low transcriptional activity of the human serotonin transporter gene …
Serotonin transporter gene polymorphism in irritable bowel syndrome
OBJECTIVES: Serotonin is a key mediator of intestinal peristalsis, and after it is secreted, it is
effectively cleansed from the neuronal gap by means of a high affinity substance called …
effectively cleansed from the neuronal gap by means of a high affinity substance called …
Family‐based association study of the serotonin transporter promoter region polymorphism (5‐HTTLPR) in attention deficit hyperactivity disorder
I Manor, J Eisenberg, S Tyano, Y Sever… - American journal of …, 2001 - Wiley Online Library
Low serotonin activity has been associated in both animal and human studies with
measures of impulsivity, aggression, and disinhibited behaviors. Recently, a common 44‐bp …
measures of impulsivity, aggression, and disinhibited behaviors. Recently, a common 44‐bp …
Monoamine transporter gene structure and polymorphisms in relation to psychiatric and other complex disorders
MK Hahn, RD Blakely - The pharmacogenomics journal, 2002 - nature.com
The norepinephrine, dopamine and serotonin transporters (NET, DAT and SERT,
respectively), limit cellular signaling by recapturing released neurotransmitter, and serve as …
respectively), limit cellular signaling by recapturing released neurotransmitter, and serve as …