Streptococcus pyogenes, also known as group A Streptococcus (GAS), causes mild human
infections such as pharyngitis and impetigo and serious infections such as necrotizing …

The cell wall envelopes of gram-positive bacteria represent a surface organelle that not only
functions as a cytoskeletal element but also promotes interactions between bacteria and …

In Gram‐positive bacteria proteins are displayed on the cell surface using sortase enzymes.
These cysteine transpeptidases join proteins bearing an appropriate sorting signal to …

Sortases are a class of bacterial enzymes that possess transpeptidase activity. It is their
ability to site‐specifically break a peptide bond and then reform a new bond with an …

Gastrointestinal (GI) diseases, and in particular those caused by bacterial infections, are a
major cause of morbidity and mortality worldwide. Treatment is becoming increasingly …

Gram‐positive bacteria pose a serious healthcare threat. The growing antibiotic resistance
epidemic creates a dire need for new antibiotic targets. The sortase family of enzymes is a …

Surface proteins are critical in determining the identifying characteristics of individual
bacteria and their interaction with the environment. Because the structure of the cell surface …

Streptococcus pyogenes (group A Streptococcus, GAS) is a human‐adapted pathogen
responsible for a wide spectrum of disease. GAS can cause relatively mild illnesses, such as …

Bacterial surface proteins are key players in host–symbiont or host–pathogen interactions.
How these proteins are targeted and displayed at the cell surface are challenging issues of …

Sortase‐mediated ligation (SML) has emerged as a powerful and versatile methodology for
site‐specific protein conjugation, functionalization/labeling, immobilization, and design of …