Despite broad scientific interest in harnessing the power of Earth's microbiomes, knowledge
gaps hinder their efficient use for addressing urgent societal and environmental challenges …

Antibiotic therapy has become increasingly ineffective against bacterial infections due to the
rise of resistance. In particular, ESKAPE pathogens (Enterococcus faecium, Staphylococcus …

Endosymbiotic bacteria have evolved intricate delivery systems that enable these organisms
to interface with host biology. One example, the extracellular contractile injection systems …

Proteins that self-assemble into polyhedral shell-like structures are useful molecular
containers both in nature and in the laboratory. Here we review efforts to repurpose diverse …

The host range of a bacteriophage is the taxonomic diversity of hosts it can successfully
infect. Host range, one of the central traits to understand in phages, is determined by a range …

Bacteriophages, the viruses infecting bacteria, hold great potential for the treatment of
multidrug-resistant bacterial infections and other applications due to their unparalleled …

The looming problem of resistance to antibiotics in microorganisms is a global health
concern. The drug-resistant microorganisms originating from anthropogenic sources and …

Bacteriophages of the Podoviridae family often exhibit so-called depolymerases as
structural components of the virion. These enzymes appear as tail spike proteins (TSPs) …

Antibiotic resistance is a major public health challenge worldwide, whose implications for
global health might be devastating if novel antibacterial strategies are not quickly …

The rapid emergence of antibiotic-resistant infections is prompting increased interest in
phage-based antimicrobials. However, acquisition of resistance by bacteria is a major issue …