Alternative splicing is a tightly regulated process whereby non-coding sequences of pre-
mRNA are removed and protein-coding segments are assembled in diverse combinations …

Only relatively recently has it become clear that mammalian genomes encode tens of
thousands of long non-coding RNAs (lncRNAs). A striking 40% of these are expressed …

Transcription factors (TFs) regulate gene programs, thereby controlling diverse cellular
processes and cell states. To comprehensively understand TFs and the programs they …

The major cell classes of the brain differ in their developmental processes, metabolism,
signaling, and function. To better understand the functions and interactions of the cell types …

Differential analysis of gene and transcript expression using high-throughput RNA
sequencing (RNA-seq) is complicated by several sources of measurement variability and …

Personalized medicine is expected to benefit from combining genomic information with
regular monitoring of physiological states by multiple high-throughput methods. Here, we …

Human astrocytes are larger and more complex than those of infraprimate mammals,
suggesting that their role in neural processing has expanded with evolution. To assess the …

Epithelial-to-mesenchymal transition (EMT) is associated with metastasis formation as well
as with generation and maintenance of cancer stem cells. In this way, EMT contributes to …

Massively parallel cDNA sequencing (RNA-Seq) provides an unbiased way to study a
transcriptome, including both coding and noncoding genes. Until now, most RNA-Seq …

Genome-wide analyses of metazoan transcriptomes have revealed an unexpected level of
mRNA diversity that is generated by alternative splicing. Recently, regulatory networks have …