The skin, being the barrier organ of the body, is constitutively exposed to various stimuli
impacting its morphology and function. Senescent cells have been found to accumulate with …

Lysosomes are membrane-bound organelles with roles in processes involved in degrading
and recycling cellular waste, cellular signalling and energy metabolism. Defects in genes …

Drug delivery to the posterior eye segment is an important challenge in ophthalmology,
because many diseases affect the retina and choroid leading to impaired vision or …

From bacteria to humans, cells secrete a large variety of membrane-bound extracellular
vesicles. Only relatively recently has it however started to become clear that the exovesicular …

Exosomes transport a variety of macromolecules and modulate intercellular communication
in physiology and disease. However, the regulation mechanisms that determine exosome …

Photoacoustic imaging allows absorption-based high-resolution spectroscopic in vivo
imaging at a depth beyond that of optical microscopy. Until recently, photoacoustic imaging …

In recent years, our vision of lysosomes has drastically changed. Formerly considered to be
mere degradative compartments, they are now recognized as key players in many cellular …

Cargo sorting to intraluminal vesicles (ILVs) of multivesicular endosomes is required for
lysosome-related organelle (LRO) biogenesis. PMEL—a component of melanocyte LROs …

Melanosomes are organelles that produce and store melanin, a widespread biological
pigment with a unique suite of properties including high refractive index, semiconducting …

Skin color, one of the most diverse human traits, is determined by the quantity, type, and
distribution of melanin. In this study, we leveraged the light-scattering properties of melanin …