[HTML][HTML] Adverse effects of COVID-19 mRNA vaccines: the spike hypothesis
Vaccination is a major tool for mitigating the coronavirus disease 2019 (COVID-19)
pandemic, and mRNA vaccines are central to the ongoing vaccination campaign that is …
pandemic, and mRNA vaccines are central to the ongoing vaccination campaign that is …
[HTML][HTML] Hypertension, thrombosis, kidney failure, and diabetes: is COVID-19 an endothelial disease? A comprehensive evaluation of clinical and basic evidence
The symptoms most commonly reported by patients affected by coronavirus disease (COVID-
19) include cough, fever, and shortness of breath. However, other major events usually …
19) include cough, fever, and shortness of breath. However, other major events usually …
Angiotensin II signal transduction: an update on mechanisms of physiology and pathophysiology
The renin-angiotensin-aldosterone system plays crucial roles in cardiovascular physiology
and pathophysiology. However, many of the signaling mechanisms have been unclear. The …
and pathophysiology. However, many of the signaling mechanisms have been unclear. The …
[HTML][HTML] ACE2 in the era of SARS-CoV-2: controversies and novel perspectives
F Saponaro, G Rutigliano, S Sestito… - Frontiers in Molecular …, 2020 - frontiersin.org
Angiotensin-converting enzyme 2 (ACE2) is related to ACE but turned out to counteract
several pathophysiological actions of ACE. ACE2 exerts antihypertensive and …
several pathophysiological actions of ACE. ACE2 exerts antihypertensive and …
[HTML][HTML] COVID-19 and the endothelium
F Jung, A Krüger-Genge, RP Franke… - Clinical …, 2020 - content.iospress.com
There is growing evidence that COVID-19 not only affects the lungs but beyond that the
endothelial system. Recent studies showed that this can lead to microcirculatory …
endothelial system. Recent studies showed that this can lead to microcirculatory …
ELABELA-APJ axis protects from pressure overload heart failure and angiotensin II-induced cardiac damage
T Sato, C Sato, A Kadowaki, H Watanabe… - Cardiovascular …, 2017 - academic.oup.com
Aims Elabela/Toddler/Apela (ELA) has been identified as a novel endogenous peptide
ligand for APJ/Apelin receptor/Aplnr. ELA plays a crucial role in early cardiac development …
ligand for APJ/Apelin receptor/Aplnr. ELA plays a crucial role in early cardiac development …
[HTML][HTML] ACE2 in chronic disease and COVID-19: gene regulation and post-translational modification
CW Wang, HC Chuang, TH Tan - Journal of Biomedical Science, 2023 - Springer
Abstract Angiotensin-converting enzyme 2 (ACE2), a counter regulator of the renin-
angiotensin system, provides protection against several chronic diseases. Besides chronic …
angiotensin system, provides protection against several chronic diseases. Besides chronic …
[HTML][HTML] Genome-wide CRISPR screen reveals host genes that regulate SARS-CoV-2 infection
Identification of host genes essential for SARS-CoV-2 infection may reveal novel therapeutic
targets and inform our understanding of COVID-19 pathogenesis. Here we performed a …
targets and inform our understanding of COVID-19 pathogenesis. Here we performed a …
[HTML][HTML] The Elabela-APJ axis: a promising therapeutic target for heart failure
Z Ma, JJ Song, S Martin, XC Yang, JC Zhong - Heart Failure Reviews, 2021 - Springer
Heart failure (HF) is a growing epidemic with high morbidity and mortality at an international
scale. The apelin–APJ receptor pathway has been implicated in HF, making it a promising …
scale. The apelin–APJ receptor pathway has been implicated in HF, making it a promising …
[HTML][HTML] HDAC inhibitor valproic acid protects heart function through Foxm1 pathway after acute myocardial infarction
Background Epigenetic histone acetylation is a major event controlling cell functions, such
as metabolism, differentiation and repair. Here, we aim to determine whether Valproic acid …
as metabolism, differentiation and repair. Here, we aim to determine whether Valproic acid …