Chronic pain (CP) is a common and often debilitating disorder that has major social and
economic impacts. A subset of patients develop CP that significantly interferes with their …

Individuals suffering from chronic pain develop substance use disorders (SUDs) more often
than others. Understanding the shared genetic influences underlying the comorbidity …

Background Observational studies have shown associations between multi-site chronic pain
(MCP) and cardiovascular disease. However, it remains unclear whether these associations …

Poor sleep is thought to enhance pain via increasing peripheral and/or central sensitization.
Aerobic exercise, conversely, relives pain via reducing sensitization, among other …

Inflammation is linked with chronic pain but the extent to which this relationship is associated
with biopsychosocial factors is not known. We investigated relationships between blood C …

Background The prevalence of depression among people with chronic pain remains unclear
due to the heterogeneity of study samples and definitions of depression. We aimed to …

Chronic pain is a common problem, with more than one-fifth of adult Americans reporting
pain daily or on most days. It adversely affects quality of life and imposes substantial …

Cardiovascular diseases (CVDs) are a leading cause of death worldwide. Early detection
and diagnosis of these diseases can greatly reduce complications and improve outcomes …

Objective Autonomic nervous system dysfunction has been implicated in chronic whiplash-
associated disorder (WAD). However, the relationship between autonomic variables (eg …

Purpose Causal mechanisms underlying systemic inflammation in spinal & widespread pain
remain an intractable experimental challenge. Here we examined whether:(i) associations …