Parenteral anticoagulants: antithrombotic therapy and prevention of thrombosis: American College of Chest Physicians evidence-based clinical practice guidelines

DA Garcia, TP Baglin, JI Weitz, MM Samama - Chest, 2012 - Elsevier
This article describes the pharmacology of approved parenteral anticoagulants. These
include the indirect anticoagulants, unfractionated heparin (UFH), low-molecular-weight …

Biochemistry and genetics of von Willebrand factor

JE Sadler - Annual review of biochemistry, 1998 - annualreviews.org
Von Willebrand factor (VWF) is a blood glycoprotein that is required for normal hemostasis,
and deficiency of VWF, or von Willebrand disease (VWD), is the most common inherited …

Heparin and low-molecular-weight heparin mechanisms of action, pharmacokinetics, dosing, monitoring, efficacy, and safety

J Hirsh, TE Warkentin, SG Shaughnessy, SS Anand… - Chest, 2001 - journal.chestnet.org
Abbreviations: ACT activated clotting time; APTT activated partial thromboplastin time; AT
antithrombin; AT-III antithrombin III; CI confidence interval; DVT deep vein thrombosis; GP …

Low-molecular-weight heparins

JI Weitz - New England Journal of Medicine, 1997 - Mass Medical Soc
After almost two decades of intensive research, low-molecular-weight heparins have
established their niche as an important class of antithrombotic compounds. The …

Adhesion mechanisms in platelet function

ZM Ruggeri, GL Mendolicchio - Circulation research, 2007 - Am Heart Assoc
Platelet adhesion is an essential function in response to vascular injury and is generally
viewed as the first step during which single platelets bind through specific membrane …

Heparin and low-molecular-weight heparin: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy

J Hirsh, R Raschke - Chest, 2004 - Elsevier
This article about unfractionated heparin (UFH) and low-molecular-weight heparin (LMWH)
is part of the Seventh American College of Chest Physicians Conference on Antithrombotic …

Perioperative blood transfusion and blood conservation in cardiac surgery: the Society of Thoracic Surgeons and The Society of Cardiovascular Anesthesiologists …

VA Ferraris, SP Ferraris, SP Saha, EA Hessel II… - The Annals of thoracic …, 2007 - Elsevier
BACKGROUND: A minority of patients having cardiac procedures (15% to 20%) consume
more than 80% of the blood products transfused at operation. Blood must be viewed as a …

Guide to anticoagulant therapy: Heparin: a statement for healthcare professionals from the American Heart Association

J Hirsh, SS Anand, JL Halperin, V Fuster - Circulation, 2001 - Am Heart Assoc
Thrombi are composed of fibrin and blood cells and may form in any part of the
cardiovascular system, including veins, arteries, the heart, and the microcirculation. Because …

Parenteral anticoagulants: American College of Chest Physicians evidence-based clinical practice guidelines

J Hirsh, KA Bauer, MB Donati, M Gould, MM Samama… - Chest, 2008 - Elsevier
This chapter describes the pharmacology of approved parenteral anticoagulants, including
the indirect anticoagulants, unfractionated heparin (UFH), low-molecular-weight heparins …

von Willebrand factor in cardiovascular disease: focus on acute coronary syndromes

AO Spiel, JC Gilbert, B Jilma - Circulation, 2008 - Am Heart Assoc
von Willebrand factor (VWF) plays a pivotal role in platelet adhesion and aggregation at
sites of high shear rates (eg, in coronary arteries that have stenotic or ruptured …