Bovine herpesvirus 1 infection and infectious bovine rhinotracheitis

B Muylkens, J Thiry, P Kirten, F Schynts, E Thiry - Veterinary research, 2007 - hal.science
Bovine herpesvirus 1 (BoHV-1), classified as an alphaherpesvirus, is a major pathogen of
cattle. Primary infection is accompanied by various clinical manifestations such as infectious …

Update on adenovirus and its vectors

WC Russell - Journal of general virology, 2000 - microbiologyresearch.org
Adenoviruses have been characterized extensively since their initial description in the early
1950s (Hillemann & Werner, 1954; Rowe et al., 1953) and there is now a panoply of …

Comparative seroprevalence and immunogenicity of six rare serotype recombinant adenovirus vaccine vectors from subgroups B and D

P Abbink, AAC Lemckert, BA Ewald, DM Lynch… - Journal of …, 2007 - Am Soc Microbiol
ABSTRACT Recombinant adenovirus serotype 5 (rAd5) vector-based vaccines are currently
being developed for both human immunodeficiency virus type 1 and other pathogens. The …

Adenoviral vector immunity: its implications and circumvention strategies

YS Ahi, DS Bangari, SK Mittal - Current gene therapy, 2011 - ingentaconnect.com
Adenoviral (Ad) vectors have emerged as a promising gene delivery platform for a variety of
therapeutic and vaccine purposes during last two decades. However, the presence of …

The effect of vaccination against porcine circovirus type 2 in pigs suffering from porcine respiratory disease complex

V Fachinger, R Bischoff, SB Jedidia, A Saalmüller… - Vaccine, 2008 - Elsevier
A field study was conducted to investigate the effect of vaccination against porcine circovirus
type 2 (PCV2) in pigs suffering from porcine respiratory disease complex (PRDC). A total of …

[HTML][HTML] Significance of preexisting vector immunity and activation of innate responses for adenoviral vector-based therapy

WC Wang, EE Sayedahmed, SK Mittal - Viruses, 2022 - mdpi.com
An adenoviral (AdV)-based vector system is a promising platform for vaccine development
and gene therapy applications. Administration of an AdV vector elicits robust innate …

Reduction of PMWS-associated clinical signs and co-infections by vaccination against PCV2

M Kixmöller, M Ritzmann, M Eddicks, A Saalmüller… - Vaccine, 2008 - Elsevier
The effects of a single-dose recombinant Porcine circovirus type 2 (PCV2) open reading
frame 2 (ORF2) subunit vaccine were studied in a post-weaning multisystemic wasting …

Development of nonhuman adenoviruses as vaccine vectors

DS Bangari, SK Mittal - Vaccine, 2006 - Elsevier
Human adenoviral (HAd) vectors have demonstrated great potential as vaccine vectors.
Preclinical and clinical studies have demonstrated the feasibility of vector design, robust …

The influence of innate and pre‐existing immunity on adenovirus therapy

AK Zaiss, HB Machado… - Journal of cellular …, 2009 - Wiley Online Library
Abstract Recombinant adenovirus serotype 5 (Ad5) vectors have been studied extensively in
preclinical gene therapy models and in a range of clinical trials. However, innate immune …

[HTML][HTML] Development of novel adenoviral vectors to overcome challenges observed with HAdV-5–based constructs

J Alonso-Padilla, T Papp, GL Kaján, M Benkő… - Molecular Therapy, 2016 - cell.com
Recombinant vectors based on human adenovirus serotype 5 (HAdV-5) have been
extensively studied in preclinical models and clinical trials over the past two decades …