Within-host HIV populations continually diversify during untreated infection, and this diversity
persists within infected cell reservoirs during antiretroviral therapy (ART). Achieving a better …

The lung is an understudied site of HIV persistence. We isolated 898 subgenomic proviral
sequences (nef) by single-genome approaches from blood and lung from nine individuals …

Curing HIV will require eliminating the reservoir of integrated, replication-competent
proviruses that persist despite antiretroviral therapy (ART). Understanding the burden …

In order to cure human immunodeficiency virus (HIV), we need to better understand the
within-host evolutionary origins of the small reservoir of genome-intact proviruses that …

Even during extended periods of effective immunological control, a substantial dynamic of
the viral genome can be observed in different cellular compartments in HIV-1 positive …

Previous studies have shown that the majority of long-lived cells harboring persistent HIV-1
proviral genomes originates from viruses circulating in the year prior to antiretroviral therapy …

Objectives Although antiretroviral therapy (ART) has prolonged the lives of HIV‐infected
individuals, HIV reservoir remains the main stumbling block to HIV cure. Presently, early …

Human immunodeficiency virus 1 (HIV) maintains an ongoing pandemic. Despite combined
antiretroviral therapies (cART) that can suppress viral load, halt progression to acquired …