The role of oxidative stress in pancreatic β cell dysfunction in diabetes
N Eguchi, ND Vaziri, DC Dafoe, H Ichii - International journal of molecular …, 2021 - mdpi.com
Diabetes is a chronic metabolic disorder characterized by inappropriately elevated glucose
levels as a result of impaired pancreatic β cell function and insulin resistance. Extensive …
levels as a result of impaired pancreatic β cell function and insulin resistance. Extensive …
Pancreatic regulation of glucose homeostasis
PV Röder, B Wu, Y Liu, W Han - Experimental & molecular medicine, 2016 - nature.com
In order to ensure normal body function, the human body is dependent on a tight control of
its blood glucose levels. This is accomplished by a highly sophisticated network of various …
its blood glucose levels. This is accomplished by a highly sophisticated network of various …
[HTML][HTML] Human beta cell mass and function in diabetes: Recent advances in knowledge and technologies to understand disease pathogenesis
Background Plasma insulin levels are predominantly the product of the morphological mass
of insulin producing beta cells in the pancreatic islets of Langerhans and the functional …
of insulin producing beta cells in the pancreatic islets of Langerhans and the functional …
Mechanism of action of Imeglimin: A novel therapeutic agent for type 2 diabetes
S Hallakou‐Bozec, G Vial, M Kergoat… - Diabetes, Obesity …, 2021 - Wiley Online Library
Imeglimin is an investigational first‐in‐class novel oral agent for the treatment of type 2
diabetes (T2D). Several pivotal phase III trials have been completed with evidence of …
diabetes (T2D). Several pivotal phase III trials have been completed with evidence of …
Regulation of insulin synthesis and secretion and pancreatic Beta-cell dysfunction in diabetes
Pancreatic β-cell dysfunction plays an important role in the pathogenesis of both type 1 and
type 2 diabetes. Insulin, which is produced in β-cells, is a critical regulator of metabolism …
type 2 diabetes. Insulin, which is produced in β-cells, is a critical regulator of metabolism …
Mechanisms of β-cell dedifferentiation in diabetes: recent findings and future research directions
M Bensellam, JC Jonas… - Journal of …, 2018 - joe.bioscientifica.com
Like all the cells of an organism, pancreatic β-cells originate from embryonic stem cells
through a complex cellular process termed differentiation. Differentiation involves the …
through a complex cellular process termed differentiation. Differentiation involves the …
The human pancreatic islet transcriptome: expression of candidate genes for type 1 diabetes and the impact of pro-inflammatory cytokines
DL Eizirik, M Sammeth, T Bouckenooghe, G Bottu… - PLoS …, 2012 - journals.plos.org
Type 1 diabetes (T1D) is an autoimmune disease in which pancreatic beta cells are killed by
infiltrating immune cells and by cytokines released by these cells. Signaling events …
infiltrating immune cells and by cytokines released by these cells. Signaling events …
Pancreatic β‐cell mass in European subjects with type 2 diabetes
J Rahier, Y Guiot, RM Goebbels… - Diabetes, Obesity …, 2008 - Wiley Online Library
Decreases in both β‐cell function and number can contribute to insulin deficiency in type 2
diabetes. Here, we quantified the β‐cell mass in pancreas obtained at autopsy of 57 type 2 …
diabetes. Here, we quantified the β‐cell mass in pancreas obtained at autopsy of 57 type 2 …
Pathogenesis of type 2 diabetes mellitus
JL Leahy - Archives of medical research, 2005 - Elsevier
The pathological sequence for type 2 diabetes is complex and entails many different
elements that act in concert to cause that disease. This review proposes a sequence of …
elements that act in concert to cause that disease. This review proposes a sequence of …
Initiation and execution of lipotoxic ER stress in pancreatic β-cells
DA Cunha, P Hekerman, L Ladrière… - Journal of cell …, 2008 - journals.biologists.com
Free fatty acids (FFA) cause apoptosis of pancreatic β-cells and might contribute to β-cell
loss in type 2 diabetes via the induction of endoplasmic reticulum (ER) stress. We studied …
loss in type 2 diabetes via the induction of endoplasmic reticulum (ER) stress. We studied …