Diabetes is a chronic metabolic disorder characterized by inappropriately elevated glucose
levels as a result of impaired pancreatic β cell function and insulin resistance. Extensive …

In order to ensure normal body function, the human body is dependent on a tight control of
its blood glucose levels. This is accomplished by a highly sophisticated network of various …

Background Plasma insulin levels are predominantly the product of the morphological mass
of insulin producing beta cells in the pancreatic islets of Langerhans and the functional …

Imeglimin is an investigational first‐in‐class novel oral agent for the treatment of type 2
diabetes (T2D). Several pivotal phase III trials have been completed with evidence of …

Pancreatic β-cell dysfunction plays an important role in the pathogenesis of both type 1 and
type 2 diabetes. Insulin, which is produced in β-cells, is a critical regulator of metabolism …

Like all the cells of an organism, pancreatic β-cells originate from embryonic stem cells
through a complex cellular process termed differentiation. Differentiation involves the …

Type 1 diabetes (T1D) is an autoimmune disease in which pancreatic beta cells are killed by
infiltrating immune cells and by cytokines released by these cells. Signaling events …

Decreases in both β‐cell function and number can contribute to insulin deficiency in type 2
diabetes. Here, we quantified the β‐cell mass in pancreas obtained at autopsy of 57 type 2 …

The pathological sequence for type 2 diabetes is complex and entails many different
elements that act in concert to cause that disease. This review proposes a sequence of …

Free fatty acids (FFA) cause apoptosis of pancreatic β-cells and might contribute to β-cell
loss in type 2 diabetes via the induction of endoplasmic reticulum (ER) stress. We studied …