How the PhoP/PhoQ System Controls Virulence and Mg2+ Homeostasis: Lessons in Signal Transduction, Pathogenesis, Physiology, and Evolution

EA Groisman, A Duprey, J Choi - Microbiology and Molecular …, 2021 - Am Soc Microbiol
SUMMARY The PhoP/PhoQ two-component system governs virulence, Mg2+ homeostasis,
and resistance to a variety of antimicrobial agents, including acidic pH and cationic …

[HTML][HTML] Magnesium is a key player in neuronal maturation and neuropathology

R Yamanaka, Y Shindo, K Oka - International journal of molecular …, 2019 - mdpi.com
Magnesium (Mg) is the second most abundant cation in mammalian cells, and it is essential
for numerous cellular processes including enzymatic reactions, ion channel functions …

Slow growth determines nonheritable antibiotic resistance in Salmonella enterica

MH Pontes, EA Groisman - Science signaling, 2019 - science.org
Bacteria can withstand killing by bactericidal antibiotics through phenotypic changes
mediated by their preexisting genetic repertoire. These changes can be exhibited transiently …

Metabolic reprogramming and longevity in quiescence

J Dworkin, CS Harwood - Annual Review of Microbiology, 2022 - annualreviews.org
Since Jacques Monod's foundational work in the 1940s, investigators studying bacterial
physiology have largely (but not exclusively) focused on the exponential phase of bacterial …

The elements of life: A biocentric tour of the periodic table

KA Remick, JD Helmann - Advances in microbial physiology, 2023 - Elsevier
Living systems are built from a small subset of the atomic elements, including the bulk
macronutrients (C, H, N, O, P, S) and ions (Mg, K, Na, Ca) together with a small but variable …

[HTML][HTML] The integral role of magnesium in muscle integrity and aging: A comprehensive review

ACR Souza, AR Vasconcelos, DD Dias, G Komoni… - Nutrients, 2023 - mdpi.com
Aging is characterized by significant physiological changes, with the degree of decline
varying significantly among individuals. The preservation of intrinsic capacity over the …

[HTML][HTML] Synergistic cancer immunotherapy utilizing programmed Salmonella typhimurium secreting heterologous flagellin B conjugated to interleukin-15 proteins

Y Zhang, W Tan, RD Sultonova, DH Nguyen, JH Zheng… - Biomaterials, 2023 - Elsevier
The use of appropriately designed immunotherapeutic bacteria is an appealing approach to
tumor therapy because the bacteria specifically target tumor tissue and deliver therapeutic …

[HTML][HTML] Microbial oxidation of arsenite: regulation, chemotaxis, phosphate metabolism and energy generation

K Shi, Q Wang, G Wang - Frontiers in Microbiology, 2020 - frontiersin.org
Arsenic (As) is a metalloid that occurs widely in the environment. The biological oxidation of
arsenite [As (III)] to arsenate [As (V)] is considered a strategy to reduce arsenic toxicity and …

Cellular Adaptations to Cytoplasmic Mg2+ Limitation

EA Groisman, C Chan - Annual review of microbiology, 2021 - annualreviews.org
Mg2+ is the most abundant divalent cation in living cells. It is essential for charge
neutralization, macromolecule stabilization, and the assembly and activity of ribosomes and …

Beneficial or harmful: Time-dependent hormesis induced by typical disinfectants and their mixtures with toxicological interaction

MT Tao, SS Liu, ZW Gu, TT Ding, P Huang - Science of The Total …, 2023 - Elsevier
Disinfectants and their mixtures can induce hormesis. However, how the mixture hormesis is
related to those of components and the interactions in disinfectant mixtures remain unclear …