Recently, heater/humidifier devices that use novel methods to condition breathing gases
from an external source have been introduced. The addition of sufficient warmth and high …

Anticholinergics are widely used for the treatment of COPD, and to a lesser extent for
asthma. Primarily used as bronchodilators, they reverse the action of vagally derived …

Background The efficacy and safety of high flow nasal therapy (HFNT) in patients with acute
hypercapnic exacerbation of chronic obstructive pulmonary disease (AECOPD) are unclear …

We studied the effects of high flow oxygen therapy (HFOT) versus non-invasive ventilation
(NIV) on inspiratory effort, as assessed by measuring transdiaphragmatic pressure …

Objectives. To describe the mechanisms and management of cold air-provoked respiratory
symptoms. Study Design. A literature review. Methods. The review includes human …

Abundant data from animal models and humans support the hypothesis that changes at the
level of parasympathetic neuronal control of airway smooth muscle result in increased …

Parasympathetic nerves provide the dominant autonomic innervation of the airways.
Release of acetylcholine from parasympathetic nerves activates postjunctional muscarinic …

Study objectives: Current options to enhance exercise performance in patients with COPD
are limited. This study compared the effects of high flows of humidified oxygen to …

The combination of heart failure and chronic obstructive pulmonary disease presents many
therapeutic challenges. The cornerstones of therapy are beta-blockers and beta-agonists …

Rationale: Exacerbation of chronic obstructive pulmonary disease commonly causes
hospitalization. The change in lung mechanics during exacerbation and its relationship to …