Gut-derived metabolite, trimethylamine-N-oxide (TMAO) in cardio-metabolic diseases: detection, mechanism, and potential therapeutics
Trimethylamine N-oxide (TMAO) is a biologically active gut microbiome-derived dietary
metabolite. Recent studies have shown that high circulating plasma TMAO levels are closely …
metabolite. Recent studies have shown that high circulating plasma TMAO levels are closely …
Lessons of vascular specialization from secondary lymphoid organ lymphatic endothelial cells
S Arroz-Madeira, T Bekkhus, MH Ulvmar… - Circulation …, 2023 - Am Heart Assoc
Secondary lymphoid organs, such as lymph nodes, harbor highly specialized and
compartmentalized niches. These niches are optimized to facilitate the encounter of naive …
compartmentalized niches. These niches are optimized to facilitate the encounter of naive …
Restoration of cervical lymphatic vessel function in aging rescues cerebrospinal fluid drainage
Cervical lymphatic vessels (cLVs) have been shown to drain solutes and cerebrospinal fluid
(CSF) from the brain. However, their hydrodynamical properties have never been evaluated …
(CSF) from the brain. However, their hydrodynamical properties have never been evaluated …
FOXC2 controls adult lymphatic endothelial specialization, function, and gut lymphatic barrier preventing multiorgan failure
A González-Loyola, E Bovay, J Kim, TW Lozano… - Science …, 2021 - science.org
The mechanisms maintaining adult lymphatic vascular specialization throughout life and
their role in coordinating inter-organ communication to sustain homeostasis remain elusive …
their role in coordinating inter-organ communication to sustain homeostasis remain elusive …
The impact of acute and chronic exercise on immunoglobulins and cytokines in elderly: insights from a critical review of the literature
M Sellami, NL Bragazzi, B Aboghaba… - Frontiers in …, 2021 - frontiersin.org
The level of immunoglobulins and cytokines changes with an ageing immune system. This
review summarizes findings from studies that have examined the impact of acute and …
review summarizes findings from studies that have examined the impact of acute and …
Lymphatic vessel: origin, heterogeneity, biological functions, and therapeutic targets
Z Hu, X Zhao, Z Wu, B Qu, M Yuan, Y Xing… - … and Targeted Therapy, 2024 - nature.com
Lymphatic vessels, comprising the secondary circulatory system in human body, play a
multifaceted role in maintaining homeostasis among various tissues and organs. They are …
multifaceted role in maintaining homeostasis among various tissues and organs. They are …
Molecular and metabolic orchestration of the lymphatic vasculature in physiology and pathology
N Montenegro-Navarro, C García-Báez… - Nature …, 2023 - nature.com
Lymphangiogenesis refers to the generation of new lymphatic vessels from pre-existing
ones. During development and particular adult states, lymphatic endothelial cells (LEC) …
ones. During development and particular adult states, lymphatic endothelial cells (LEC) …
Clinical potential of adrenomedullin signaling in the cardiovascular system
Numerous clinical studies have revealed the utility of circulating AM (adrenomedullin) or MR-
proAM (mid-regional proAM 45-92) as an effective prognostic and diagnostic biomarker for a …
proAM (mid-regional proAM 45-92) as an effective prognostic and diagnostic biomarker for a …
The novel role of lymphatic vessels in the pathogenesis of ocular diseases
T Clahsen, K Hadrian, M Notara, SL Schlereth… - Progress in Retinal and …, 2023 - Elsevier
Historically, the eye has been considered as an organ free of lymphatic vessels. In recent
years, however, it became evident, that lymphatic vessels or lymphatic-like vessels …
years, however, it became evident, that lymphatic vessels or lymphatic-like vessels …
Targeting Synovial Lymphatic Function as a Novel Therapeutic Intervention for Age‐Related Osteoarthritis in Mice
X Lin, RD Bell, SE Catheline, T Takano… - Arthritis & …, 2023 - Wiley Online Library
Objective The synovial lymphatic system (SLS) removes catabolic factors from the joint.
Vascular endothelial growth factor C (VEGF‐C) and its receptor, VEGFR‐3, are crucial for …
Vascular endothelial growth factor C (VEGF‐C) and its receptor, VEGFR‐3, are crucial for …