Gut-derived metabolite, trimethylamine-N-oxide (TMAO) in cardio-metabolic diseases: detection, mechanism, and potential therapeutics

M Shanmugham, S Bellanger, CH Leo - Pharmaceuticals, 2023 - mdpi.com
Trimethylamine N-oxide (TMAO) is a biologically active gut microbiome-derived dietary
metabolite. Recent studies have shown that high circulating plasma TMAO levels are closely …

Lessons of vascular specialization from secondary lymphoid organ lymphatic endothelial cells

S Arroz-Madeira, T Bekkhus, MH Ulvmar… - Circulation …, 2023 - Am Heart Assoc
Secondary lymphoid organs, such as lymph nodes, harbor highly specialized and
compartmentalized niches. These niches are optimized to facilitate the encounter of naive …

Restoration of cervical lymphatic vessel function in aging rescues cerebrospinal fluid drainage

T Du, A Raghunandan, H Mestre, V Plá, G Liu… - Nature Aging, 2024 - nature.com
Cervical lymphatic vessels (cLVs) have been shown to drain solutes and cerebrospinal fluid
(CSF) from the brain. However, their hydrodynamical properties have never been evaluated …

FOXC2 controls adult lymphatic endothelial specialization, function, and gut lymphatic barrier preventing multiorgan failure

A González-Loyola, E Bovay, J Kim, TW Lozano… - Science …, 2021 - science.org
The mechanisms maintaining adult lymphatic vascular specialization throughout life and
their role in coordinating inter-organ communication to sustain homeostasis remain elusive …

The impact of acute and chronic exercise on immunoglobulins and cytokines in elderly: insights from a critical review of the literature

M Sellami, NL Bragazzi, B Aboghaba… - Frontiers in …, 2021 - frontiersin.org
The level of immunoglobulins and cytokines changes with an ageing immune system. This
review summarizes findings from studies that have examined the impact of acute and …

Lymphatic vessel: origin, heterogeneity, biological functions, and therapeutic targets

Z Hu, X Zhao, Z Wu, B Qu, M Yuan, Y Xing… - … and Targeted Therapy, 2024 - nature.com
Lymphatic vessels, comprising the secondary circulatory system in human body, play a
multifaceted role in maintaining homeostasis among various tissues and organs. They are …

Molecular and metabolic orchestration of the lymphatic vasculature in physiology and pathology

N Montenegro-Navarro, C García-Báez… - Nature …, 2023 - nature.com
Lymphangiogenesis refers to the generation of new lymphatic vessels from pre-existing
ones. During development and particular adult states, lymphatic endothelial cells (LEC) …

Clinical potential of adrenomedullin signaling in the cardiovascular system

L Bálint, NP Nelson-Maney, Y Tian, SD Serafin… - Circulation …, 2023 - Am Heart Assoc
Numerous clinical studies have revealed the utility of circulating AM (adrenomedullin) or MR-
proAM (mid-regional proAM 45-92) as an effective prognostic and diagnostic biomarker for a …

The novel role of lymphatic vessels in the pathogenesis of ocular diseases

T Clahsen, K Hadrian, M Notara, SL Schlereth… - Progress in Retinal and …, 2023 - Elsevier
Historically, the eye has been considered as an organ free of lymphatic vessels. In recent
years, however, it became evident, that lymphatic vessels or lymphatic-like vessels …

Targeting Synovial Lymphatic Function as a Novel Therapeutic Intervention for Age‐Related Osteoarthritis in Mice

X Lin, RD Bell, SE Catheline, T Takano… - Arthritis & …, 2023 - Wiley Online Library
Objective The synovial lymphatic system (SLS) removes catabolic factors from the joint.
Vascular endothelial growth factor C (VEGF‐C) and its receptor, VEGFR‐3, are crucial for …