Collagen receptor signalling in platelets: extending the role of the ITAM
Recent studies have shown that activation of platelets by collagen is mediated through the
same pathway as that used by immune receptors, with pivotal roles for an immunoreceptor …
same pathway as that used by immune receptors, with pivotal roles for an immunoreceptor …
Thromboxane A2: its generation and role in platelet activation
H Arita, T Nakano, K Hanasaki - Progress in lipid research, 1989 - Elsevier
In 1969, Piper and Vane! discovered a labile substance elaborated during anaphylaxis in
guinea pig lung and named it rabbit aorta contracting substance (RCS). In 1975, Hamberg et …
guinea pig lung and named it rabbit aorta contracting substance (RCS). In 1975, Hamberg et …
Enhancement by N-hydroxysulfosuccinimide of water-soluble carbodiimide-mediated coupling reactions
Water-soluble carbodiimides are frequently employed in coupling or conjugation reactions,
eg, to link a peptide immunogen to a carrier protein. However, their utility is limited by low …
eg, to link a peptide immunogen to a carrier protein. However, their utility is limited by low …
Integrin α 2 β 1-independent activation of platelets by simple collagen-like peptides: collagen tertiary (triple-helical) and quaternary (polymeric) structures are sufficient …
LF Morton, PG Hargreaves, RW Farndale… - Biochemical …, 1995 - portlandpress.com
The platelet reactivities of two simple collagen-like synthetic peptides, Gly-Lys-Hyp-(Gly-Pro-
Hyp) 10-Gly-Lys-Hyp-Gly and Gly-Cys-Hyp-(Gly-Pro-Hyp) 10-Gly-Cys-Hyp-Gly, were …
Hyp) 10-Gly-Lys-Hyp-Gly and Gly-Cys-Hyp-(Gly-Pro-Hyp) 10-Gly-Cys-Hyp-Gly, were …
Identification of a 160,000 dalton platelet membrane protein that mediates the initial divalent cation-dependent adhesion of platelets to collagen
SA Santoro - Cell, 1986 - Elsevier
Platelets initially adhere to collagen via a divalent cation-dependent process supported by
Mg 2+, Mn 2+, Fe 2+, Cu 2+, Zn 2+, or Co 2+ more rapidly and to a greater extent than by …
Mg 2+, Mn 2+, Fe 2+, Cu 2+, Zn 2+, or Co 2+ more rapidly and to a greater extent than by …
A novel platelet aggregating factor found in a patient with defective collagen-induced platelet aggregation and autoimmune thrombocytopenia
T Sugiyama, M Okuma, F Ushikubi, S Sensaki, K Kanaji… - 1987 - ashpublications.org
We found a novel platelet aggregating factor in a patient with steroid-responsive immune
thrombocytopenic purpura that is associated with defective collagen-induced platelet …
thrombocytopenic purpura that is associated with defective collagen-induced platelet …
The membrane glycoprotein Ia-IIa (VLA-2) complex mediates the Mg++-dependent adhesion of platelets to collagen.
WD Staatz, SM Rajpara, EA Wayner… - The Journal of cell …, 1989 - rupress.org
We have purified the platelet membrane glycoprotein Ia-IIa complex by detergent
solubilization and sequential affinity chromatography on Concanavalin A-Sepharose and …
solubilization and sequential affinity chromatography on Concanavalin A-Sepharose and …
Collagen-platelet interactions: evidence for a direct interaction of collagen with platelet GPIa/IIa and an indirect interaction with platelet GPIIb/IIIa mediated by adhesive …
BS Coller, JH Beer, LE Scudder, MH Steinberg - 1989 - ashpublications.org
Using intact human platelets as the immunogen and a functional, collagen-coated bead
agglutination assay, we have produced a murine monoclonal antibody (6F1) that blocks the …
agglutination assay, we have produced a murine monoclonal antibody (6F1) that blocks the …
Formation and regulation of platelet and fibrin hemostatic plug
J Hawiger - Human pathology, 1987 - Elsevier
Formation of a hemostatic plug represents one of the earliest responses to vessel wall injury.
Platelets react to any discontinuity in the vascular endothelium through initial contact …
Platelets react to any discontinuity in the vascular endothelium through initial contact …
The human fibroblast class II extracellular matrix receptor mediates platelet adhesion to collagen and is identical to the platelet glycoprotein Ia-IIa complex.
TJ Kunicki, DJ Nugent, SJ Staats… - Journal of Biological …, 1988 - Elsevier
A monoclonal antibody, P1H5, to the human fibroblast class II extracellular matrix receptor
(ECMR II) specifically inhibits human fibroblast adhesion to collagen and …
(ECMR II) specifically inhibits human fibroblast adhesion to collagen and …