The regulation of body temperature is one of the most critical functions of the nervous
system. Here we review our current understanding of thermoregulation in mammals. We …

The endocannabinoid (eCB) system has attracted attention for its role in various behavioral
and brain functions, and as a therapeutic target in neuropsychiatric disease states, including …

Body temperature regulation is a fundamental homeostatic function that is governed by the
central nervous system in homeothermic animals, including humans. The central …

Transient receptor potential (TRP) channels are important mediators of sensory signals with
marked effects on cellular functions and signalling pathways. Indeed, mutations in genes …

Thermoregulation is one of the most vital functions of the brain, but how temperature
information is converted into homeostatic responses remains unknown. Here, we use an …

Transient receptor potential (TRP) cation channels have been among the most aggressively
pursued drug targets over the past few years. Although the initial focus of research was on …

The detection and processing of painful stimuli in afferent sensory neurons is critically
dependent on a wide range of different types of voltage-and ligand-gated ion channels …

Human and mouse thermal physiology differ due to dissimilar body sizes. Unexpectedly, in
mice we found no ambient temperature zone where both metabolic rate and body …

Despite affecting millions of individuals, the etiology of hot flushes remains unknown. Here
we review the physiology of hot flushes, CNS pathways regulating heat-dissipation effectors …

Heat exchange processes between the body and the environment are introduced. The
definition of the thermoneutral zone as the ambient temperature range within which body …