A comprehensive understanding of RNA structure will provide fundamental insights into the
cellular function of both coding and non-coding RNAs. Although many RNA structures have …

RNA is arguably the most versatile biological macromolecule because of its ability both to
encode and to manipulate genetic information. The diverse roles of RNA depend on its …

Background Accurate modeling of electrostatic potential and corresponding energies
becomes increasingly important for understanding properties of biological macromolecules …

Large noncoding RNAs fold into their biologically functional structures via compact yet
disordered intermediates, which couple the stable secondary structure of the RNA with the …

Magnesium ions play an essential role in many vital processes. To correctly describe their
interactions in molecular dynamics simulations, an accurate parametrization is crucial …

The continual improvement of methods for RNA 3D structure modeling and prediction
requires accurate and statistically meaningful data concerning RNA structure, both for …

Divalent metal ions are of fundamental importance to the function and folding of nucleic
acids. Divalent metal ion–nucleic acid interactions are complex in nature and include both …

The prevalence of Mg2+ ions in biology and their essential role in nucleic acid structure and
function has motivated the development of various Mg2+ ion models for use in molecular …

Many non-coding RNAs fold into complex three-dimensional structures, yet the self-
assembly of RNA structure is hampered by mispairing, weak tertiary interactions …

Intermediates play important roles in RNA folding but can be difficult to characterize when
short-lived or not significantly populated. By combining 15N relaxation dispersion NMR with …