Diversity in connexin biology

SA Lucaciu, SE Leighton, A Hauser, R Yee… - Journal of Biological …, 2023 - ASBMB
Over 35 years ago the cell biology community was introduced to connexins as the subunit
employed to assemble semicrystalline clusters of intercellular channels that had been well …

Connexins in epidermal health and diseases: insights into their mutations, implications, and therapeutic solutions

SS Yasarbas, E Inal, MA Yildirim, S Dubrac… - Frontiers in …, 2024 - frontiersin.org
The epidermis, the outermost layer of the skin, serves as a protective barrier against external
factors. Epidermal differentiation, a tightly regulated process essential for epidermal …

Connexin Hemichannel Inhibition and Human Genodermatoses

F Mammano, AS Paller, TW White - Journal of Investigative Dermatology, 2024 - Elsevier
Pathogenic variants in genes encoding connexins that cause skin diseases, such as keratitis–
ichthyosis–deafness (KID) syndrome and hidrotic ectodermal dysplasia (HED) or Clouston …

Generation of Connexin-Expressing Stable Cell Pools

A Tettey-Matey, C Di Pietro, V Donati… - … : Methods and Protocols, 2024 - Springer
Stable cell pools have the advantage of providing a definite, consistent, and reproducible
transmission of a transgene of interest, compared to transient expression from a plasmid …

A Protocol for the Automated Assessment of Cutaneous Pathology in a Mouse Model of Hemichannel Dysfunction

C Peres, F Mammano - Connexin Hemichannels: Methods and Protocols, 2024 - Springer
In this chapter, we provide detailed instructions to perform quantitative reflectance imaging
in a mouse model of a rare epidermal disorder caused by hyperactive connexin 26 …