Symptomatic hemorrhagic transformation (HT) is one of the complications most likely to lead
to death in patients with acute ischemic stroke. HT after acute ischemic stroke is diagnosed …

Hemorrhagic transformation (HT) is a common complication of ischemic stroke that is
exacerbated by thrombolytic therapy. Methods to better prevent, predict, and treat HT are …

Rationale: Hemorrhagic complications represent a major limitation of intravenous
thrombolysis using tPA (tissue-type plasminogen activator) in patients with ischemic stroke …

While the mainstay of acute stroke treatment includes revascularization via recombinant
tissue plasminogen activator or mechanical thrombectomy, only a minority of stroke patients …

Ischemic stroke (IS) is one of the most fatal diseases. Neuroimmunity, inflammation, and
oxidative stress play important roles in various complex mechanisms of IS. In particular, the …

Background—Inflammatory and immune responses triggered by brain ischemia worsen
clinical outcomes of stroke and contribute to hemorrhagic transformation, massive edema …

Peripheral lymphocytes entering brain ischemic regions orchestrate inflammatory
responses, catalyze tissue death, and worsen clinical outcomes of acute ischemic stroke …

Rationale: Cerebrovascular function is critical for brain health, and endogenous vascular
protective pathways may provide therapeutic targets for neurological disorders. S1P …

Importance Pronounced inflammatory reactions occurring shortly after intracerebral
hemorrhage (ICH) contribute to the formation and progression of perihematomal edema …

Ischemic stroke, caused by a sudden disruption of blood flow to the brain, is a leading cause
of death and exerts a heavy burden on both patients and public health systems. Currently …