Natural killer (NK) cells are innate immune cells that show strong cytolytic function against
physiologically stressed cells such as tumor cells and virus-infected cells. NK cells show a …

In recent years, roles of the immune system in immune surveillance of cancer have been
explored using a variety of approaches. The roles of the adaptive immune system have been …

Natural killer (NK) cells circulate through the blood, lymphatics and tissues, on patrol for the
presence of transformed or pathogen-infected cells. As almost all NK cell receptors bind to …

Natural killer (NK) cells are potent immune effector cells that can respond to infection and
cancer, as well as allowing maternal adaptation to pregnancy. In response to malignant …

A growing body of research is addressing how pathways that are dysregulated during
tumorigenesis are linked to innate immune responses, which can contribute to immune …

In cancer, immune exhaustion contributes to the immunosuppressive tumor
microenvironment. Exhausted immune cells demonstrate poor effector function and …

CD48, a member of the signaling lymphocyte activation molecule family, participates in
adhesion and activation of immune cells. Although constitutively expressed on most …

Commitment to the T and natural killer T (NKT) cell lineages is determined during αβ T cell
receptor (TCR)-mediated interactions of common precursors with ligand-expressing cells in …

Multiple inhibitory receptors may play a role in the weak or absent CD8+ T‐cell response in
chronic hepatitis B virus (HBV) infection. Yet few receptors have been characterized in detail …

The signalling lymphocytic activation molecule (SLAM) family of receptors is expressed by a
wide range of immune cells. Through their cytoplasmic domain, SLAM family receptors …