Context: Colorectal cancer is one of the most common cancers worldwide. Epigenetic
alterations play an important role in the pathogenesis of the colorectal cancer. Objective …

The adenomatous polyposis coli (APC) gene, known as tumor suppressor gene, has the two
promoters 1A and 1B. Researches on APC have usually focused on its loss-of-function …

DNA methylation is the most frequent epigenetic alteration. Using methylation-specific
polymerase chain reaction (MSP), the methylation status of the adenomatous polyposis coli …

Current asthma treatments may control the symptoms of asthma but do not modify its natural
history. Epigenetic mechanisms and novel explanatory models provide burgeoning …

Background: Epidemiological studies have shown that smoking increases the risk for
colorectal cancer (CRC). Evidence of the guiding significance of smoking history for …

Colorectal cancer (CRC) is the leading cause of cancer death worldwide. A crucial process
that initiates and progresses CRC is various epigenetic and genetic changes occurring in …

Objective Colorectal cancer (CRC) and hypodontia are frequent and different diseases with
common genes are involved in their etiology. The objective of this study was to identify the …

AXIN2, an important regulator in Wnt/β-catenin signaling pathway, takes part in regulating
cell proliferation, cytometaplasia, migration, apoptosis and other important functions, has …

Background Numerous studies have reported the correlation between AXIN2 polymorphism
and cancer risk, but the results seem not consistent. In order to get an overall, accurate and …

Background Colorectal cancer (CRC) is one the leading causes of cancer related deaths
among Iranians. Despite the various progresses in new therapeutic methods, it has still a …