DNA methylation-based predictors of health: applications and statistical considerations
DNA methylation data have become a valuable source of information for biomarker
development, because, unlike static genetic risk estimates, DNA methylation varies …
development, because, unlike static genetic risk estimates, DNA methylation varies …
An ecologist's guide for studying DNA methylation variation in wild vertebrates
The field of molecular biology is advancing fast with new powerful technologies, sequencing
methods and analysis software being developed constantly. Commonly used tools originally …
methods and analysis software being developed constantly. Commonly used tools originally …
Detection and accurate false discovery rate control of differentially methylated regions from whole genome bisulfite sequencing
With recent advances in sequencing technology, it is now feasible to measure DNA
methylation at tens of millions of sites across the entire genome. In most applications …
methylation at tens of millions of sites across the entire genome. In most applications …
Calling differentially methylated regions from whole genome bisulphite sequencing with DMRcate
Whole genome bisulphite sequencing (WGBS) permits the genome-wide study of single
molecule methylation patterns. One of the key goals of mammalian cell-type identity studies …
molecule methylation patterns. One of the key goals of mammalian cell-type identity studies …
DMRcaller: a versatile R/Bioconductor package for detection and visualization of differentially methylated regions in CpG and non-CpG contexts
M Catoni, JMF Tsang, AP Greco… - Nucleic acids …, 2018 - academic.oup.com
DNA methylation has been associated with transcriptional repression and detection of
differential methylation is important in understanding the underlying causes of differential …
differential methylation is important in understanding the underlying causes of differential …
CpG-island-based annotation and analysis of human housekeeping genes
By reviewing previous CpG-related studies, we consider that the transcription regulation of
about half of the human genes, mostly housekeeping (HK) genes, involves CpG islands …
about half of the human genes, mostly housekeeping (HK) genes, involves CpG islands …
Analysis of DNA modifications in aging research
As geroscience research extends into the role of epigenetics in aging and age-related
disease, researchers are being confronted with unfamiliar molecular techniques and data …
disease, researchers are being confronted with unfamiliar molecular techniques and data …
Contrasting DNA methylation responses of inbred fish lines to different rearing environments
WM Berbel-Filho, D Rodríguez-Barreto, N Berry… - Epigenetics, 2019 - Taylor & Francis
Epigenetic mechanisms generate plastic phenotypes that can become locally adapted
across environments. Disentangling genomic from epigenomic variation is challenging in …
across environments. Disentangling genomic from epigenomic variation is challenging in …
A multi-cohort and multi-omics meta-analysis framework to identify network-based gene signatures
Although massive amounts of condition-specific molecular profiles are being accumulated in
public repositories every day, meaningful interpretation of these data remains a major …
public repositories every day, meaningful interpretation of these data remains a major …
Population epigenomics: advancing understanding of phenotypic plasticity, acclimation, adaptation and diseases
Advances in chromatin state mapping, high-throughput DNA sequencing, and bioinformatics
have revolutionized the study and interpretability of epigenomic variation. The increasing …
have revolutionized the study and interpretability of epigenomic variation. The increasing …