In eukaryotic cells, DNA is tightly packed with the help of histone proteins into chromatin.
Chromatin architecture can be modified by various post‐translational modifications of …

Posttranslational modifications, typically small chemical tags attached on amino acids
following protein biosynthesis, have a profound effect on protein structure and function …

Protein acetylation is a central event in orchestrating diverse cellular processes. However,
current strategies to investigate protein acetylation in cells are often nonspecific or lack …

Peptides are privileged ligands for diverse biomacromolecules, including proteins; however,
their utility is often limited due to low membrane permeability and in-cell instability. Here, we …

The term “undruggable” refers to proteins or other biological targets that have been
historically challenging to target with conventional drugs or therapeutic strategies because …

Lysine acylation plays pivotal roles in cell physiology, including DNA transcription and
repair, signal transduction, immune defense, metabolism, and many other key cellular …

Using a chemical approach to crosslink functionally versatile bioeffectors (such as peptides)
to native proteins of interest (POI) directly inside a living cell is a useful toolbox for chemical …

Selective methods for introducing protein post-translational modifications (PTMs) within
living cells have proven valuable for interrogating their biological function. In contrast to …

Chemically engineered biomacromolecules (eg, proteins) offer great opportunities to
investigate fundamental chemical biology and develop novel therapeutics. With the …

Conspectus There is a continuous demand to improve our understanding of fundamental
processes that underlie human health and disease. Therefore, novel strategies that can …