Heparin has been recognized as a valuable anticoagulant and antithrombotic for several
decades and is still widely used in clinical practice for a variety of indications. The …

Glycosaminoglycans (GAGs) are important complex carbohydrates that participate in many
biological processes through the regulation of their various protein partners. Biochemical …

Thrombospondins are evolutionarily conserved, calcium-binding glycoproteins that undergo
transient or longer-term interactions with other extracellular matrix components. They share …

Extracellular vesicles (EVs) are released into blood from multiple organs and carry
molecular cargo that facilitates inter-organ communication and an integrated response to …

The essential role of protein–glycosaminoglycan interactions in the regulation of various
physiological processes has been recognized for several decades but it is only recently that …

Matrix metalloproteases regulate both physiological and pathological events by processing
matrix proteins and growth factors. ADAMTS1 in particular is required for normal ovulation …

Introduction 3. Complex structures finely regulated 3.1. The heparan sulfate proteoglycans
3.2. Regulation of chain expression 4. Regulation of cell function 4.1. Human diseases and …

Thrombospondins are large secreted, multimodular, calcium-binding glycoproteins that have
complex roles in mediating cellular processes. Determination of high-resolution structures of …

In biofluids, charged functional groups on the surface of nanoparticles (NPs) interact with
cells through the protein corona. However, the cascade effects of charged groups on corona …

Crohn disease (CD), a sub-entity of inflammatory bowel disease (IBD), is a complex
polygenic disorder. Although recent studies have successfully identified CD-associated …