TET-mediated active DNA demethylation: mechanism, function and beyond
In mammals, DNA methylation in the form of 5-methylcytosine (5mC) can be actively
reversed to unmodified cytosine (C) through TET dioxygenase-mediated oxidation of 5mC to …
reversed to unmodified cytosine (C) through TET dioxygenase-mediated oxidation of 5mC to …
Clonal hematopoiesis, somatic mosaicism, and age-associated disease
MA Evans, K Walsh - Physiological Reviews, 2023 - journals.physiology.org
Somatic mosaicism, the occurrence of multiple genetically distinct cell clones within the
same tissue, is an evitable consequence of human aging. The hematopoietic system is no …
same tissue, is an evitable consequence of human aging. The hematopoietic system is no …
Dynamics of clonal evolution in myelodysplastic syndromes
To elucidate differential roles of mutations in myelodysplastic syndromes (MDS), we
investigated clonal dynamics using whole-exome and/or targeted sequencing of 699 …
investigated clonal dynamics using whole-exome and/or targeted sequencing of 699 …
Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation
K Moran-Crusio, L Reavie, A Shih, O Abdel-Wahab… - Cancer cell, 2011 - cell.com
Somatic loss-of-function mutations in the ten-eleven translocation 2 (TET2) gene occur in a
significant proportion of patients with myeloid malignancies. Although there are extensive …
significant proportion of patients with myeloid malignancies. Although there are extensive …
What a difference a hydroxyl makes: mutant IDH,(R)-2-hydroxyglutarate, and cancer
JA Losman, WG Kaelin - Genes & development, 2013 - genesdev.cshlp.org
Mutations in metabolic enzymes, including isocitrate dehydrogenase 1 (IDH1) and IDH2, in
cancer strongly implicate altered metabolism in tumorigenesis. IDH1 and IDH2 catalyze the …
cancer strongly implicate altered metabolism in tumorigenesis. IDH1 and IDH2 catalyze the …
Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2
TET2 is a close relative of TET1, an enzyme that converts 5-methylcytosine (5mC) to 5-
hydroxymethylcytosine (5hmC) in DNA,. The gene encoding TET2 resides at chromosome …
hydroxymethylcytosine (5hmC) in DNA,. The gene encoding TET2 resides at chromosome …
[HTML][HTML] TET2 inactivation results in pleiotropic hematopoietic abnormalities in mouse and is a recurrent event during human lymphomagenesis
Loss-of-function mutations affecting one or both copies of the Ten-Eleven-translocation
(TET) 2 gene have been described in various human myeloid malignancies. We report that …
(TET) 2 gene have been described in various human myeloid malignancies. We report that …
Prognostic score including gene mutations in chronic myelomonocytic leukemia
R Itzykson, O Kosmider, A Renneville… - Journal of clinical …, 2013 - ascopubs.org
Purpose Several prognostic scoring systems have been proposed for chronic
myelomonocytic leukemia (CMML), a disease in which some gene mutations—including …
myelomonocytic leukemia (CMML), a disease in which some gene mutations—including …
Active DNA demethylation: many roads lead to Rome
SC Wu, Y Zhang - Nature reviews Molecular cell biology, 2010 - nature.com
DNA methylation is one of the best-characterized epigenetic modifications and has been
implicated in numerous biological processes, including transposable element silencing …
implicated in numerous biological processes, including transposable element silencing …
[HTML][HTML] Crystal structure of TET2-DNA complex: insight into TET-mediated 5mC oxidation
Summary TET proteins oxidize 5-methylcytosine (5mC) on DNA and play important roles in
various biological processes. Mutations of TET2 are frequently observed in myeloid …
various biological processes. Mutations of TET2 are frequently observed in myeloid …