Immune cells and glia interact with neurons to alter pain sensitivity and to mediate the
transition from acute to chronic pain. In response to injury, resident immune cells are …

In a large proportion of individuals nervous system damage may lead to a debilitating
chronic neuropathic pain. Such pain may now be considered a neuro-immune disorder …

Humans detect tactile stimuli through a combination of pressure and vibration signals using
different types of cutaneous receptor. The development of artificial tactile perception systems …

The complement system is a part of the immune system and consists of multiple complement
components with biological functions such as defense against pathogens and …

The activation of the complement cascade, a cornerstone of the innate immune response,
produces a number of small (74–77 amino acid) fragments, originally termed …

The complement cascade is a key component of the innate immune system that is rapidly
recruited through a cascade of enzymatic reactions to enable the recognition and clearance …

Chronic pain is a major debilitating condition that is difficult to treat. Although chronic pain
may appear to be a disorder of the nervous system, crucial roles for immune cells and their …

Existing microarray gene expression profiling studies of tonic/chronic pain were subjected to
meta-analysis to identify genes found to be regulated by these pain states in multiple …

Neuropathic pain after spinal cord injury (SCI) is common, often intractable, and can be
severely debilitating. A number of mechanisms have been proposed for this pain, which are …

Extensive infiltration by tumor-associated macrophages (TAM) in combination with myeloid-
derived suppressor cells constitute the immunosuppressive microenvironment and promote …