Molecular and cellular mechanisms of salt taste

A Taruno, MD Gordon - Annual Review of Physiology, 2023 - annualreviews.org
Salt taste, the taste of sodium chloride (NaCl), is mechanistically one of the most complex
and puzzling among basic tastes. Sodium has essential functions in the body but causes …

Illuminating subcortical GABAergic and glutamatergic circuits for reward and aversion

A Gordon-Fennell, GD Stuber - Neuropharmacology, 2021 - Elsevier
Reinforcement, reward, and aversion are fundamental processes for guiding appropriate
behaviors. Longstanding theories have pointed to dopaminergic neurons of the ventral …

Love is a physiological motivation (like hunger, thirst, sleep or sex)

E Burunat - Medical hypotheses, 2019 - Elsevier
The multitude of terms associated with love has given rise to a false perception of love. In
this paper, only maternal and romantic love are considered. Love is usually regarded as a …

Investigating the effect of physiological need states on palatability and motivation using microstructural analysis of licking

F Naneix, KZ Peters, JE McCutcheon - Neuroscience, 2020 - Elsevier
The study of consummatory responses during food intake represents a unique opportunity to
investigate the physiological, psychological and neurobiological processes that control …

Dopaminergic contributions to behavioral control under threat of punishment in rats

JPH Verharen, MCM Luijendijk… - …, 2020 - Springer
Rationale Excessive intake of rewards, such as food and drugs, often has explicit negative
consequences, including the development of obesity and addiction, respectively. Thus …

Interference with the renin-angiotensin system reduces the palatability of 0.3 M NaCl in sodium-deplete rats

AA Zenatti, ED Pereira Jr, J Possari, CAF Andrade… - Appetite, 2021 - Elsevier
The renin-angiotensin system (RAS) controls hypertonic NaCl intake driven by sodium
appetite. Here we investigated whether the antagonism of RAS interferes with hedonic and …

Computational mechanisms of osmoregulation: a reinforcement learning model for sodium appetite

Y Uchida, T Hikida, Y Yamashita - Frontiers in Neuroscience, 2022 - frontiersin.org
Homeostatic control with oral nutrient intake is a vital complex system involving the orderly
interactions between the external and internal senses, behavioral control, reward learning …

Parallel neural pathways control sodium consumption and taste valence

Y Zhang, AH Pool, T Wang, L Liu, E Kang, B Zhang… - Cell, 2023 - cell.com
The hedonic value of salt fundamentally changes depending on the internal state. High
concentrations of salt induce innate aversion under sated states, whereas such aversive …