Filopodia are dynamic cell surface protrusions used for cell motility, pathogen infection, and
tissue development. The molecular mechanisms determining how and where filopodia grow …

Ductal carcinoma in situ (DCIS) is a pre-invasive form of breast cancer where neoplastic
luminal cells are confined to the ductal tree. While as many as 70% of DCIS cases will …

Live-cell super-resolution microscopy enables the imaging of biological structure dynamics
below the diffraction limit. Here we present enhanced super-resolution radial fluctuations …

Metastasis of colorectal cancer (CRC) is a leading cause of mortality among CRC patients.
Elevated COX-2 and PD-L1 expression in colon cancer tissue has been linked to distant …

Integrin-mediated cell adhesion is essential for cell migration, mechanotransduction and
tissue integrity. In vivo, these processes are regulated by complex physicochemical signals …

The progression of noninvasive ductal carcinoma in situ to invasive ductal carcinoma for
patients with breast cancer results in a significantly poorer prognosis and is the precursor to …

Class III myosins localize to inner ear hair cell stereocilia and are thought to be crucial for
stereocilia length regulation. Mutations within the motor domain of MYO3A that disrupt its …

The current cancer research and drug testing are primarily based on 2D cell cultures and
animal models. However, these methods have limitations and yield distinct drug response …

In life sciences, tracking objects from movies enables researchers to quantify the behavior of
single particles, organelles, bacteria, cells, and even whole animals. While numerous tools …

Confined cells migrating through 3D environments are also constrained by the laws of
physics, meaning for every action there must be an equal and opposite reaction for cells to …