Spatiotemporal gene expression programmes are orchestrated by transcriptional
enhancers, which are key regulatory DNA elements that engage in physical contacts with …

In eukaryotes, the genome does not exist as a linear molecule but instead is hierarchically
packaged inside the nucleus. This complex genome organization includes multiscale …

INTRODUCTION Mammalian genes that play prominent roles in healthy and diseased
cellular states are often controlled by special DNA elements called super-enhancers (SEs) …

There is considerable evidence that chromosome structure plays important roles in gene
control, but we have limited understanding of the proteins that contribute to structural …

Phase-separated multi-molecular assemblies provide a general regulatory mechanism to
compartmentalize biochemical reactions within cells. We propose that a phase separation …

Cyclins, cyclin-dependent kinases and other components of the core cell cycle machinery
drive cell division. Growing evidence indicates that this machinery operates in a distinct …

The molecular mechanisms underlying folding of mammalian chromosomes remain poorly
understood. The transcription factor CTCF is a candidate regulator of chromosomal …

Cancer arises from genetic alterations that invariably lead to dysregulated transcriptional
programs. These dysregulated programs can cause cancer cells to become highly …

Mammalian DNA methylation is a critical epigenetic mechanism orchestrating gene
expression networks in many biological processes. However, investigation of the functions …

The three-dimensional configuration of DNA is integral to all nuclear processes in
eukaryotes, yet our knowledge of the chromosome architecture is still limited. Genome-wide …