The complex functions of the liver in biosynthesis, metabolism, clearance, and host defense
are tightly dependent on an adequate microcirculation. To guarantee hepatic homeostasis …

Ischemia-reperfusion injury is, at least in part, responsible for the morbidity associated with
liver surgery under total vascular exclusion or after liver transplantation. The …

High-mobility group box 1 (HMGB1) is a nuclear factor that is released extracellularly as a
late mediator of lethality in sepsis as well as after necrotic, but not apoptotic, death. Here we …

The hepatocyte is especially vulnerable to injury due to its central role in xenobiotic
metabolism including drugs and alcohol, participation in lipid and fatty acid metabolism, its …

Background & Aims: An earlier pilot study from our liver unit suggested benefit from
treatment with pentoxifylline (PTX), an inhibitor of tumor necrosis factor (TNF), in severe …

Ischemia-reperfusion injury (IRI) is the main cause of morbidity and mortality due to graft
rejection after liver transplantation. During IRI, an intense inflammatory process occurs in the …

Ischemic tissues require mechanisms to alert the immune system of impending cell damage.
The nuclear protein high-mobility group box 1 (HMGB1) can activate inflammatory pathways …

Background: The morbidity associated with liver transplantation and major hepatic
resections is partly a result of ischemia-reperfusion injury. Data Sources: The entire world …

Hepatic ischemia-reperfusion injury is commonplace in liver surgery, particularly in hepatic
transplantation, hepatic resection, and trauma. The signaling events contributing to local …

This review highlights recent advances in our understanding of mechanisms underlying
reperfusion injury to the liver after warm hepatic ischemia. Sinusoidal endothelial cells and …