In spite of the remarkable progress in basic and preclinical studies of acute myeloid
leukemia (AML), the five-year survival rate of AML patients remains poor, highlighting the …

The plasma membrane of eukaryotic cells is not a simple sheet of lipids and proteins but is
differentiated into subdomains with crucial functions. Caveolae, small pits in the plasma …

In inflammatory CNS conditions such as multiple sclerosis (MS), current options to treat
clinical relapse are limited, and more selective agents are needed. Disruption of the blood …

The biological and clinical behaviors of hematological malignancies can be influenced by
the active crosstalk with an altered bone marrow (BM) microenvironment. In the present …

Vascular endothelial growth factor (VEGF) is an endothelial cell-specific mitogen in vitro and
an angiogenic inducer in a variety of in vivo models. Hypoxia has been shown to be a major …

Nitric oxide (NO) and nitric oxide synthases are ubiquitous in malignant tumours and are
known to exert both pro-and anti-tumour effects. We summarize our current understanding of …

Mechanotransduction is a key determinant of tissue homeostasis and tumor progression. It is
driven by intercellular adhesions, cell contractility, and forces generated within the …

Diet and obesity are important risk factors for cancer development. Many studies have
suggested an important role for several dietary nutrients in the progression and …

Nitric oxide (NO) is a pleiotropic molecule critical to a number of physiological and
pathological processes. The last decade has witnessed major advances in dissecting NO …

Caveolae are 50-to 100-nm omega-shaped invaginations of the plasma membrane that
function as regulators of signal transduction. Caveolins are a class of oligomeric structural …