γδ T-cells directly recognize and kill transformed cells independently of HLA-antigen
presentation, which makes them a highly promising effector cell compartment for cancer …

The intricacy of diseases, shaped by intrinsic processes like immune system exhaustion and
hyperactivation, highlights the potential of immune renormalization as a promising strategy …

Abstract γδ T cells play uniquely important roles in stress surveillance and immunity for
infections and carcinogenesis. Human γδ T cells recognize and kill transformed cells …

Colorectal cancer (CRC) is highly heterogeneous at the genetic and molecular level, which
has major repercussions on the efficacy of immunotherapy. A small subset of CRCs exhibit …

The term bispecific antibody (bsAb) is used to describe a large family of molecules designed
to recognize two different epitopes or antigens. BsAbs come in many formats, ranging from …

Clinical responses to checkpoint inhibitors used for cancer immunotherapy seemingly
require the presence of αβT cells that recognize tumour neoantigens, and are therefore …

Abstract Vγ9Vδ2 T cells are promising candidates for cellular tumor immunotherapy. Due to
their HLA-independent mode of action, allogeneic Vγ9Vδ2 T cells can be considered for …

The potential of cancer immunotherapy relies on the mobilization of immune cells capable of
producing antitumour cytokines and effectively killing tumour cells. These are major …

Immunotherapy is now the standard of care for advanced hepatocellular carcinoma (HCC),
yet many patients fail to respond. A major unmet goal is the boosting of T-cells with both …

Abstract γδT cells have been reported to exert immunosuppressive functions in multiple
solid malignant diseases, but their immunosuppressive functional subpopulation in breast …