Background Few reports have aimed to describe the mediational effect of cognitive deficits
on functional outcomes in major depressive disorder (MDD), and relatively few interventions …

Major depressive disorder is a common condition with a high rate of recurrence, chronicity,
and staggering economic burden, including disability in the workforce. 1 In 2010, MDD was …

The hypothalamic–pituitary–adrenal (HPA) axis has been implicated in the pathophysiology
of a variety of mood and cognitive disorders. Neuroendocrine studies have demonstrated …

The efficacy of vortioxetine 10 and 20 mg/d vs. placebo on cognitive function and depression
in adults with recurrent moderate-to-severe major depressive disorder (MDD) was …

Objective The primary objective of this review is to examine the literature assessing
abnormalities in neural circuitry and cognition early in the course of major depressive …

A thorough understanding of the cognitive effects of antidepressant medications is essential
given their frequency of use. This meta-analysis was conducted to investigate whether …

The effects of major depressive disorder (MDD) on neurocognitive function remain poorly
understood. Results from published studies vary widely in terms of methodological factors …

As the population ages, the economic and societal impacts of neurodegenerative and
neuropsychiatric disorders are expected to rise sharply. Like dementia, late-life depressive …

Background Mental health problems are common within the working population. Depression
is both highly prevalent and debilitating and is linked to increases in absenteeism and …

Cognitive deficits are frequently observed in major depressive disorder (MDD), as well as
impaired long-term psychosocial functioning. However, the relationship between cognitive …