Apoptosis by Death Factor: Cell Skip to Main Content Advertisement Cell This journal offers
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CD40 is a cell surface receptor that belongs to the tumor necrosis factor‐R (TNF‐R) family,
and that was first identified and functionally characterized on B lymphocytes. Its critical role …

B cells are activated by two temporally distinct signals, the first provided by the binding of
antigen to the B cell antigen receptor (BCR), and the second provided by helper T cells …

FAS belongs to the subgroup of the tumor necrosis factor receptor (TNF-R) family that
contains an intracellular" death domain" and triggers apoptosis. Its physiological ligand …

Virtually all of the measurable cell-mediated cytotoxicity delivered by cytotoxic T
lymphocytes and natural killer cells comes from either the granule exocytosis pathway or the …

Gene targeting experiments have demonstrated that the expression of immunoglobulin
heavy chain in the pre-B cell receptor (pBCR) and of heavy and light chains in the B cell …

Fas, a TNF family receptor, is activated by the membrane protein Fas ligand expressed on
various immune cells. Fas signaling triggers apoptosis and induces inflammatory cytokine …

▪ Abstract Apoptosis of mature T lymphocytes preserves peripheral homeostasis and
tolerance by countering the profound changes in the number and types of T cells stimulated …

In 1989 we published a paper describing the discovery of an apoptosis-inducing receptor
[1]. We named this receptor APO-1, anticipating that it might be the first of a series of …

Today, multiple lines of evidence support the view of atherosclerosis as a chronic
inflammatory disease and implicate components of the immune system in atherogenesis …