For decades, basic research on the underlying mechanisms of nociception has held promise
to translate into efficacious treatments for patients with pain. Despite great improvement in …

Somatosensation and pain are complex phenomena involving a rangeofspecialised cell
types forming different circuits within the peripheral and central nervous systems. In recent …

Background Diffuse noxious inhibitory controls (DNIC) as measured in rat and conditioned
pain modulation (CPM), the supposed psychophysical paradigm of DNIC measured in …

Bone cancer pain is a common symptom in cancer patients with bone metastases and its
underlying mechanisms remain unknown. Here, we report that Runx1 directly upregulates …

Pain is one of the most debilitating symptoms of rheumatoid arthritis (RA), and yet remains
poorly understood, especially when pain occurs in the absence of synovitis. Without active …

Simple Summary The mechanisms that underlie pain resulting from metastatic bone disease
remain elusive. This translates to a clinical and socioeconomic burden—targeted therapy is …

Chemotherapy-induced peripheral neuropathy (CIPN) affects∼ 68% of patients undergoing
chemotherapy, causing debilitating neuropathic pain and reducing quality of life. Cisplatin is …

Cancer-induced bone pain (CIBP) is considered to be one of the most difficult pain
conditions to treat. Morphine, an analgesic drug, is widely used in clinical practice, and long …

Nerve terminals within the tumor microenvironment as potential pain-mitigating targets for
local infiltration analgesia is relatively less explored. In this study, we examine the role of key …

Ca2+ imaging can be used as a proxy for cellular activity, including action potentials and
various signaling mechanisms involving Ca2+ entry into the cytoplasm or the release of …