Superantigens are unconventional antigens which recognise immune receptors outside
their usual recognition sites eg complementary determining regions (CDRs), to elicit a …

Inflammatory bowel disease (IBD), as a chronic and recurrent inflammatory disorder, is
caused by a dysregulated and aberrant immune response to exposed environmental factors …

Rationale: The incidence of hepatocellular carcinoma is rising worldwide. It is predicted that
nearly half of the early-stage hepatocellular carcinoma (E-HCC) patients will develop …

Gastric cancer remains one of the most lethal and prevalent malignancies, particularly in
China. The majority of patients are diagnosed with gastric cancer at the late stages of the …

Despite their simple structure, the Notch family of receptors regulates a wide-spectrum of key
cellular processes including development, tissue patterning, cell-fate determination …

MicroRNAs (miRNAs) are key regulators in the development and progression of
osteosarcoma (OS). Based on our previous microarray data, we found that miR-335 …

Acute lymphoblastic leukemia (ALL), one of the most common malignant human disorders,
originates in different important genetic lesions in T‐cell or B‐cell progenitors. ALL is a …

Abstract cAMP response element binding protein 1 (CREB1, CREB) is a key transcription
factor that mediates transcriptional responses to a variety of growth factors and stress …

Background Prostate cancer is one of the most common and socially significant cancers
among men. The aim of our study was to reveal changes in miRNA expression profiles …

MicroRNAs (miRNAs) are endogenous mediators of RNA interference and have key roles in
the modulation of gene expression under healthy, inflamed, stimulated, carcinogenic, or …