Complex rearrangement patterns and mitotic errors are hallmarks of most pancreatic ductal
adenocarcinomas (PDAC), a disease with dismal prognosis despite some therapeutic …

In recent years, synthetic lethality has been recognized as a solid paradigm for anticancer
therapies. The discovery of a growing number of synthetic lethal targets has led to a …

Pancreatic ductal adenocarcinoma (PDAC) has one of the highest mortality rates among all
cancer types. Its delayed diagnosis precludes curative resection, thus most of the current …

The dysregulation of apoptosis and DNA damage repair are two leading mechanisms of
cisplatin resistance. Two anticancer PtIV prodrugs with the formulas [Pt (NH3) 2Cl2 (L1) 2](1 …

Homologous recombination (HR) is involved in repairing DNA double-strand breaks (DSB),
the most harmful for the cell. Regulating HR is essential for maintaining genomic stability. In …

Background Triple-negative breast cancer (TNBC) affects young women and is the most
aggressive subtype of breast cancer (BC). TNBCs disproportionally affect women of African …

The effective potency and resistance of poly (ADP-ribose) polymerase (PARP) inhibitors limit
their application. Here, we exploit a new paradigm that mimics the effects of breast cancer …

Personalized medicine and therapies represent the goal of modern medicine, as drug
discovery strives to move away from one-cure-for-all and makes use of the various targets …

Targeting DNA repair proteins with small-molecule inhibitors became a proven anti-cancer
strategy. Previously, we identified an inhibitor of a major protein of homologous …

Alterations in DNA repair pathways are one of the main drivers of cancer insurgence.
Nevertheless, cancer cells are more susceptible to DNA damage than normal cells and they …