The cellular membrane constitutes one of the most fundamental compartments of a living
cell, where key processes such as selective transport of material and exchange of …

Atomic-resolution structural studies of membrane-associated proteins and peptides in a
membrane environment are important to fully understand their biological function and the …

Although polymer-based lipid nanodiscs are increasingly used in the structural studies of
membrane proteins, the charge of the belt-forming polymer is a major limitation for functional …

There is considerable interest in the development of membrane mimetics to study the
structure, dynamics and function of membrane proteins. Polymer nanodiscs have been …

Lipid-bilayer nanodiscs provide a stable, native-like membrane environment for the
functional and structural studies of membrane proteins and other membrane-binding …

We review the use of molecular dynamics (MD) simulation as a drug design tool in the
context of the role that the lipid membrane can play in drug action, ie, the interaction …

Lipids can play important roles in modulating membrane protein structure and function.
However, it is challenging to identify natural lipids bound to membrane proteins in complex …

The nanodisc technology is increasingly used for structural studies on membrane proteins
and drug delivery. The development of synthetic polymer nanodiscs and the recent …

Polymers can facilitate detergent-free extraction of membrane proteins into nanodiscs (eg,
SMALPs, DIBMALPs), incorporating both integral membrane proteins as well as co …

Although there is a growing interest in using polymer lipid-nanodiscs, the polymer charge
poses limitations for studies on membrane proteins. Here, we demonstrate the functional …