ETS-domain transcription-factor networks represent a model for how combinatorial gene
expression is achieved. These transcription factors interact with a multitude of co-regulatory …

ETS-related gene (ERG) is a member of the E-26 transformation-specific (ETS) family of
transcription factors with roles in development that include vasculogenesis, angiogenesis …

ETS proteins are a group of evolutionarily related, DNA-binding transcriptional factors.
These proteins direct gene expression in diverse normal and disease states by binding to …

The polypeptide chains that make up proteins have thousands of atoms and hence millions
of possible inter-atomic interactions. It might be supposed that the resulting complexity …

The Ets1 proto-oncoprotein is a member of the Ets family of transcription factors that share a
unique DNA binding domain, the Ets domain. The DNA binding activity of Ets1 is controlled …

Ets1 belongs to the large family of the ETS domain family of transcription factors and is
involved in cancer progression. In most carcinomas, Ets1 expression is linked to poor …

Protein-protein interactions are essential for the assembly, regulation, and localization of
functional protein complexes in the cell. SAM domains are among the most abundant protein …

TEL is a transcriptional repressor that is a frequent target of chromosomal translocations in a
large number of hematalogical malignancies. These rearrangements fuse a potent …

Cell signaling that culminates in posttranslational modifications directs protein activity. Here
we report how multiple Ca2+-dependent phosphorylation sites within the transcription …

Summary EGFR-RAS-ERK signaling promotes growth and proliferation in many cell types,
and genetic hyperactivation of RAS-ERK signaling drives many cancers. Yet, despite …