Endoplasmic reticulum quality control (ERQC) pathways comprising chaperones, folding
enzymes, and degradation factors ensure the fidelity of ER protein folding and trafficking to …

The endoplasmic reticulum (ER) represents the entry point into the secretory pathway where
nascent proteins encounter a specialized environment for their folding and maturation …

Genome-wide association studies (GWASs) have identified hundreds of loci associated with
Crohn's disease (CD). However, as with all complex diseases, robust identification of the …

As sessile organisms, plants are exposed to persistently changing stresses and have to be
able to interpret and respond to them. The stresses, drought, salinity, chemicals, cold and …

Vesicular stomatitis virus (VSV) exhibits a remarkably robust and pantropic infectivity,
mediated by its coat protein, VSV-G. Using this property, recombinant forms of VSV and VSV …

Perturbations in endoplasmic reticulum (ER) homeostasis, including depletion of Ca 2+ or
altered redox status, induce ER stress due to protein accumulation, misfolding and …

Background Alzheimer's disease is the most prevalent cause of dementia in the elderly.
Neuronal death and synaptic dysfunctions are considered the main hallmarks of this …

The endoplasmic reticulum (ER) is the major folding compartment for secreted and
membrane proteins and is the site of a specific chaperone system, the calnexin cycle, for …

Unfolded and malfolded client proteins impose a stress on the endoplasmic reticulum (ER),
which contributes to cell death in pathophysiological conditions. The transcription factor …

Analysis of the human genome reveals that approximately a third of all open reading frames
code for proteins that enter the endoplasmic reticulum (ER), demonstrating the importance of …