A modern understanding of how cerebral cortical lesions develop after acute brain injury is
based on Aristides Leão's historic discoveries of spreading depression and asphyxial/anoxic …

Despite the enormous progress in the understanding of the course of the ischemic stroke
over the last few decades, a therapy that effectively protects neurovascular units (NVUs) and …

2622 Stroke September 2017 cerebral edema and symptomatic intracranial hemorrhage,
which defines a malignant profile. 27 Because such patients have lowest rates of favorable …

Spreading depolarizations (SD) are waves of abrupt, near-complete breakdown of neuronal
transmembrane ion gradients, are the largest possible pathophysiologic disruption of viable …

The term spreading depolarization describes a wave in the gray matter of the central
nervous system characterized by swelling of neurons, distortion of dendritic spines, a large …

The term spreading depolarization (SD) refers to waves of abrupt, sustained mass
depolarization in gray matter of the CNS. SD, which spreads from neuron to neuron in …

Background When a patient arrives in the emergency department following a stroke, a
traumatic brain injury, or sudden cardiac arrest, there is no therapeutic drug available to help …

Ischemic stroke is a devastating disease with a complex pathophysiology. Animal modeling
of ischemic stroke serves as an indispensable tool first to investigate mechanisms of …

Progressive ischaemic damage in animals is associated with spreading mass
depolarizations of neurons and astrocytes, detected as spreading negative slow voltage …

Cytotoxic brain edema triggered by neuronal swelling is the chief cause of mortality
following brain trauma and cerebral infarct. Using fluorescence lifetime imaging to analyze …