Therapeutic potential and pharmaceutical development of a multitargeted flavonoid phloretin

KT Nakhate, H Badwaik, R Choudhary, K Sakure… - Nutrients, 2022 - mdpi.com
Phloretin is a flavonoid of the dihydrogen chalcone class, present abundantly in apples and
strawberries. The beneficial effects of phloretin are mainly associated with its potent …

The molecular pharmacology of phloretin: anti-inflammatory mechanisms of action

S Habtemariam - Biomedicines, 2023 - mdpi.com
The isolation of phlorizin from the bark of an apple tree in 1835 led to a flurry of research on
its inhibitory effect on glucose transporters in the intestine and kidney. Using phlorizin as a …

Fabrication and characterization of oil-in-water emulsions stabilized by whey protein isolate/phloridzin/sodium alginate ternary complex

J Li, S Geng, S Zhen, X Lv, B Liu - Food Hydrocolloids, 2022 - Elsevier
Whey protein isolate (WPI) is an important food supplement and natural surfactant. Emulsion
systems based on WPI and WPI–polyphenol complex have been the focus of food delivery …

[HTML][HTML] Anti-aging effect of phlorizin on D-galactose–induced aging in mice through antioxidant and anti-inflammatory activity, prevention of apoptosis, and regulation …

H Chen, L Dong, X Chen, C Ding, M Hao, X Peng… - Experimental …, 2022 - Elsevier
Aging is an inevitable and complicated process involving many physiological changes.
Screening of natural biologically active anti-aging substances is a current research hotspot …

Antibacterial modes of herbal flavonoids combat resistant bacteria

L Song, X Hu, X Ren, J Liu, X Liu - Frontiers in Pharmacology, 2022 - frontiersin.org
The increasing dissemination of multidrug resistant (MDR) bacterial infections endangers
global public health. How to develop effective antibacterial agents against resistant bacteria …

Isolation and biological activity of natural chalcones based on antibacterial mechanism classification

S Wang, C Li, L Zhang, B Sun, Y Cui, F Sang - Bioorganic & Medicinal …, 2023 - Elsevier
Bacterial infection, which is still one of the leading causes of death in humans, poses an
enormous threat to the worldwide public health system. Antibiotics are the primary …

[HTML][HTML] Impact of levetiracetam on cognitive impairment, neuroinflammation, oxidative stress, and neuronal apoptosis caused by lipopolysaccharides in rats

V Mani, SR Almutairi - Saudi Pharmaceutical Journal, 2023 - Elsevier
Introduction Neuroinflammation is associated with the elevation of toxic proinflammatory
mediators that promote neurodegeneration and subsequently affect cognition. Causes of …

Anti-Oxidant and Anti-Aging Effects of Phlorizin Are Mediated by DAF-16-Induced Stress Response and Autophagy in Caenorhabditis elegans

S Park, SK Park - Antioxidants, 2022 - mdpi.com
Phlorizin (phloridzin) is a polyphenolic phytochemical primarily found in unripe Malus
(apple). It is a glucoside of phloretin and acts as an inhibitor of renal glucose transport, thus …

Role of sodium-glucose co-transporter 2 inhibitors in the regulation of inflammatory processes in animal models

S Feijóo-Bandín, A Aragón-Herrera… - International Journal of …, 2022 - mdpi.com
Sodium-glucose co-transporter 2 inhibitors, also known as gliflozins, were developed as a
novel class of anti-diabetic agents that promote glycosuria through the prevention of glucose …

Antioxidant and Anti-Inflammatory Properties of Phytochemicals Found in the Yucca Genus

EB Culhuac, A Maggiolino, MMMY Elghandour… - Antioxidants, 2023 - mdpi.com
The Yucca genus encompasses about 50 species native to North America. Species within
the Yucca genus have been used in traditional medicine to treat pathologies related to …