Detecting epistasis in human complex traits
Genome-wide association studies (GWASs) have become the focus of the statistical analysis
of complex traits in humans, successfully shedding light on several aspects of genetic …
of complex traits in humans, successfully shedding light on several aspects of genetic …
Genetic modifiers and rare Mendelian disease
KMTH Rahit, M Tarailo-Graovac - Genes, 2020 - mdpi.com
Despite advances in high-throughput sequencing that have revolutionized the discovery of
gene defects in rare Mendelian diseases, there are still gaps in translating individual …
gene defects in rare Mendelian diseases, there are still gaps in translating individual …
A survey about methods dedicated to epistasis detection
During the past decade, findings of genome-wide association studies (GWAS) improved our
knowledge and understanding of disease genetics. To date, thousands of SNPs have been …
knowledge and understanding of disease genetics. To date, thousands of SNPs have been …
Travelling the world of gene–gene interactions
K Van Steen - Briefings in bioinformatics, 2012 - academic.oup.com
Over the last few years, main effect genetic association analysis has proven to be a
successful tool to unravel genetic risk components to a variety of complex diseases. In the …
successful tool to unravel genetic risk components to a variety of complex diseases. In the …
An overview of SNP interactions in genome-wide association studies
With the recent explosion in high-throughput genotyping technology, the amount and quality
of single-nucleotide polymorphism (SNP) data has increased exponentially. Therefore, the …
of single-nucleotide polymorphism (SNP) data has increased exponentially. Therefore, the …
MACOED: a multi-objective ant colony optimization algorithm for SNP epistasis detection in genome-wide association studies
PJ Jing, HB Shen - Bioinformatics, 2014 - academic.oup.com
Motivation: The existing methods for genetic-interaction detection in genome-wide
association studies are designed from different paradigms, and their performances vary …
association studies are designed from different paradigms, and their performances vary …
epiACO-a method for identifying epistasis based on ant Colony optimization algorithm
Y Sun, J Shang, JX Liu, S Li, CH Zheng - BioData mining, 2017 - Springer
Background Identifying epistasis or epistatic interactions, which refer to nonlinear interaction
effects of single nucleotide polymorphisms (SNPs), is essential to understand disease …
effects of single nucleotide polymorphisms (SNPs), is essential to understand disease …
MTHSA-DHEI: multitasking harmony search algorithm for detecting high-order SNP epistatic interactions
Genome-wide association studies have succeeded in identifying genetic variants associated
with complex diseases, but the findings have not been well interpreted biologically. Although …
with complex diseases, but the findings have not been well interpreted biologically. Although …
A review on methods for detecting SNP interactions in high-dimensional genomic data
S Uppu, A Krishna, RP Gopalan - IEEE/ACM transactions on …, 2016 - ieeexplore.ieee.org
In this era of genome-wide association studies (GWAS), the quest for understanding the
genetic architecture of complex diseases is rapidly increasing more than ever before. The …
genetic architecture of complex diseases is rapidly increasing more than ever before. The …
Niche harmony search algorithm for detecting complex disease associated high-order SNP combinations
S Tuo, J Zhang, X Yuan, Z He, Y Liu, Z Liu - Scientific reports, 2017 - nature.com
Genome-wide association study is especially challenging in detecting high-order disease-
causing models due to model diversity, possible low or even no marginal effect of the model …
causing models due to model diversity, possible low or even no marginal effect of the model …