Immune dysregulation and immunopathology induced by SARS-CoV-2 and related coronaviruses—are we our own worst enemy?

LYR Wong, S Perlman - Nature Reviews Immunology, 2022 - nature.com
Human coronaviruses cause a wide spectrum of disease, ranging from mild common colds
to acute respiratory distress syndrome and death. Three highly pathogenic human …

Interplay between SARS-CoV-2 and the type I interferon response

M Sa Ribero, N Jouvenet, M Dreux, S Nisole - PLoS pathogens, 2020 - journals.plos.org
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is responsible for the
current COVID-19 pandemic. An unbalanced immune response, characterized by a weak …

Therapeutic options for the 2019 novel coronavirus (2019-nCoV)

G Li, E De Clercq - Nature reviews Drug discovery, 2020 - nature.com
Therapeutic options for the 2019 novel coronavirus (2019-nCoV) Skip to main content Thank
you for visiting nature.com. You are using a browser version with limited support for CSS. To …

Targeting liquid–liquid phase separation of SARS-CoV-2 nucleocapsid protein promotes innate antiviral immunity by elevating MAVS activity

S Wang, T Dai, Z Qin, T Pan, F Chu, L Lou, L Zhang… - Nature Cell …, 2021 - nature.com
Patients with Coronavirus disease 2019 exhibit low expression of interferon-stimulated
genes, contributing to a limited antiviral response. Uncovering the underlying mechanism of …

[HTML][HTML] Renal histopathological analysis of 26 postmortem findings of patients with COVID-19 in China

H Su, M Yang, C Wan, LX Yi, F Tang, HY Zhu, F Yi… - Kidney international, 2020 - Elsevier
Although the respiratory and immune systems are the major targets of Coronavirus Disease
2019 (COVID-19), acute kidney injury and proteinuria have also been observed. Currently …

From SARS to SARS-CoV-2, insights on structure, pathogenicity and immunity aspects of pandemic human coronaviruses

N Kirtipal, S Bharadwaj, SG Kang - Infection, Genetics and Evolution, 2020 - Elsevier
Abstract Human Coronaviruses (HCoV), periodically emerging across the world, are
potential threat to humans such as severe acute respiratory syndrome coronavirus-2 (SARS …

α-Ketoamides as broad-spectrum inhibitors of coronavirus and enterovirus replication: structure-based design, synthesis, and activity assessment

L Zhang, D Lin, Y Kusov, Y Nian, Q Ma… - Journal of medicinal …, 2020 - ACS Publications
The main protease of coronaviruses and the 3C protease of enteroviruses share a similar
active-site architecture and a unique requirement for glutamine in the P1 position of the …

[HTML][HTML] SARS-coronavirus-2 replication in Vero E6 cells: replication kinetics, rapid adaptation and cytopathology

NS Ogando, TJ Dalebout… - Journal of General …, 2020 - microbiologyresearch.org
The sudden emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
at the end of 2019 from the Chinese province of Hubei and its subsequent pandemic spread …

A unifying structural and functional model of the coronavirus replication organelle: Tracking down RNA synthesis

EJ Snijder, RWAL Limpens, AH de Wilde… - PLoS …, 2020 - journals.plos.org
Zoonotic coronavirus (CoV) infections, such as those responsible for the current severe
acute respiratory syndrome-CoV 2 (SARS-CoV-2) pandemic, cause grave international …

SARS-CoV-2 triggers an MDA-5-dependent interferon response which is unable to control replication in lung epithelial cells

A Rebendenne, AL Chaves Valadão, M Tauziet… - Journal of …, 2021 - Am Soc Microbiol
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiologic agent of
coronavirus disease 19 (COVID-19), which ranges from mild respiratory symptoms to acute …